NPTX1

Neuronal pentraxin-1 (NP1) is a protein that in humans is encoded by the NPTX1 gene.

NPTX1
Identifiers
Aliases	NPTX1, NP1, neuronal pentraxin 1
External IDs	OMIM: 602367; MGI: 107811; HomoloGene: 1891; GeneCards: NPTX1; OMA:NPTX1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q25.3 Start 80,466,834 bp End 80,477,843 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 E2|11 83.95 cM Start 119,429,545 bp End 119,438,579 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis paraflocculus of cerebellum middle temporal gyrus frontal pole right hemisphere of cerebellum parietal lobe postcentral gyrus superior frontal gyrus Brodmann area 10 orbitofrontal cortex Top expressed in lobe of cerebellum cerebellar vermis dentate gyrus of hippocampal formation granule cell primary motor cortex subiculum habenula prefrontal cortex ventromedial nucleus anterior amygdaloid area hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding Cellular component transport vesicle cytoplasmic vesicle plasma membrane neuron projection glutamatergic synapse Biological process central nervous system development axonogenesis involved in innervation chemical synaptic transmission regulation of postsynaptic neurotransmitter receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4884 18164 Ensembl ENSG00000171246 ENSMUSG00000025582 UniProt Q15818 Q62443 RefSeq (mRNA) NM_002522 NM_008730 RefSeq (protein) NP_002513 NP_032756 Location (UCSC) Chr 17: 80.47 – 80.48 Mb Chr 11: 119.43 – 119.44 Mb PubMed search
Wikidata
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Function

NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system.

Further reading

• Kirkpatrick LL, Matzuk MM, Dodds DC, Perin MS (2000). "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2". J. Biol. Chem. 275 (23): 17786–92. doi:10.1074/jbc.M002254200. PMID 10748068.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Abad MA, Enguita M, DeGregorio-Rocasolano N, et al. (2006). "Neuronal pentraxin 1 contributes to the neuronal damage evoked by amyloid-beta and is overexpressed in dystrophic neurites in Alzheimer's brain". J. Neurosci. 26 (49): 12735–47. doi:10.1523/JNEUROSCI.0575-06.2006. PMC 6674827. PMID 17151277.
• Takahashi T, Strittmatter SM (2001). "Plexina1 autoinhibition by the plexin sema domain". Neuron. 29 (2): 429–39. doi:10.1016/S0896-6273(01)00216-1. PMID 11239433.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Poulsen TT, Pedersen N, Perin MS, et al. (2005). "Specific sensitivity of small cell lung cancer cell lines to the snake venom toxin taipoxin". Lung Cancer. 50 (3): 329–37. doi:10.1016/j.lungcan.2005.06.011. PMID 16115696.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.