NADH:ubiquinone oxidoreductase complex assembly factor 8 is a protein that in humans is encoded by the NDUFAF8 gene.[4] This protein stabilizes NDUFAF5 during assembly of mitochondrial Complex I.[5]
| NDUFAF8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | NDUFAF8, C17orf89, NADH:ubiquinone oxidoreductase complex assembly factor 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 618461; MGI: 1913676; HomoloGene: 83602; GeneCards: NDUFAF8; OMA:NDUFAF8 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
| |||||||||||||||||||||||||||||||||||||||||||||||||||
Structure
editThe NDUFAF8 gene is located on the q arm of chromosome 17 in position 25.3 and spans 1,987 base pairs.[4] The gene produces a 7.756 kDa protein composed of 74 amino acids.[6][7]
Function
editThe protein encoded by the NDUFAF8 gene is involved in the assembly of mitochondrial Complex I (NADH-ubiquinone oxidoreductase). This protein is required to stabilize NDUFAF5 during assembly of Complex I.[5]
Interaction
editNDUFAF8 has protein-protein interactions with NDUFAF5, stabilizing it.[5]
References
edit- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000078572 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: NADH:ubiquinone oxidoreductase complex assembly factor 8". Retrieved 2018-07-27.
- ^ a b c "NDUFAF8 - NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8 - Homo sapiens (Human) - NDUFAF8 gene & protein". www.uniprot.org. Retrieved 2018-07-27.
- ^ Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (Oct 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
- ^ "Uncharacterized protein C17orf89". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Archived from the original on 2018-07-28. Retrieved 2018-07-27.
Further reading
editThis article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it. |