NCAPD2

Condensin complex subunit 1 also known as chromosome-associated protein D2 (CAP-D2) or non-SMC condensin I complex subunit D2 (NCAPD2) or XCAP-D2 homolog is a protein that in humans is encoded by the NCAPD2 gene. CAP-D2 is a subunit of condensin I, a large protein complex involved in chromosome condensation.

NCAPD2
Identifiers
Aliases	NCAPD2, CAP-D2, CNAP1, hCAP-D2, non-SMC condensin I complex subunit D2, MCPH21
External IDs	OMIM: 615638; MGI: 1915548; HomoloGene: 6497; GeneCards: NCAPD2; OMA:NCAPD2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12p13.31 Start 6,493,356 bp End 6,531,955 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 F2- F3 Start 125,144,970 bp End 125,168,664 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence bone marrow cells stromal cell of endometrium granulocyte rectum epithelium of colon gonad Descending thoracic aorta gastric mucosa Top expressed in tail of embryo ventricular zone genital tubercle mandibular prominence yolk sac maxillary prominence thymus spermatocyte epiblast somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone binding chromatin binding protein binding Cellular component cytoplasm membrane chromosome nucleoplasm condensin complex nuclear chromosome condensed chromosome nucleus condensed chromosome, centromeric region cytosol Biological process mitotic chromosome condensation meiotic chromosome condensation cell division chromosome separation chromosome condensation cell cycle mitotic cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9918 68298 Ensembl ENSG00000010292 ENSMUSG00000038252 UniProt Q15021 Q8K2Z4 RefSeq (mRNA) NM_014865 NM_146171 RefSeq (protein) NP_055680 NP_666283 Location (UCSC) Chr 12: 6.49 – 6.53 Mb Chr 6: 125.14 – 125.17 Mb PubMed search
Wikidata
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Further reading

• Simon MA (1999). "Racial, ethnic, and gender diversity and the resident operative experience. How can the Academic Orthopaedic Society shape the future of orthopaedic surgery?". Clin. Orthop. Relat. Res. 360 (360): 253–9. doi:10.1097/00003086-199903000-00031. PMID 10101332.
• Collas P, Le Guellec K, Taskén K (2000). "The A-kinase-anchoring protein AKAP95 is a multivalent protein with a key role in chromatin condensation at mitosis". J. Cell Biol. 147 (6): 1167–80. doi:10.1083/jcb.147.6.1167. PMC 2168084. PMID 10601332.
• Kimura K, Cuvier O, Hirano T (2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". J. Biol. Chem. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719.
• Ball AR, Schmiesing JA, Zhou C, et al. (2002). "Identification of a chromosome-targeting domain in the human condensin subunit CNAP1/hCAP-D2/Eg7". Mol. Cell. Biol. 22 (16): 5769–81. doi:10.1128/MCB.22.16.5769-5781.2002. PMC 133980. PMID 12138188.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.