NANOS1

Nanos homolog 1 (Drosophila) is a protein that in humans is encoded by the NANOS1 gene.

NANOS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CQO
Identifiers
Aliases	NANOS1, NOS1, SPGF12, EC_Rep1a, NOS-1, nanos homolog 1 (Drosophila), ZC2HC12A, nanos C2HC-type zinc finger 1
External IDs	OMIM: 608226; MGI: 2669254; HomoloGene: 131234; GeneCards: NANOS1; OMA:NANOS1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q26.11 Start 119,029,714 bp End 119,033,730 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 D3 Start 60,744,425 bp End 60,748,352 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Skeletal muscle tissue of biceps brachii vastus lateralis muscle Skeletal muscle tissue of rectus abdominis muscle of thigh retinal pigment epithelium gastrocnemius muscle deltoid muscle tibialis anterior muscle left adrenal cortex Top expressed in Rostral migratory stream zygote supraoptic nucleus secondary oocyte nucleus accumbens dorsal striatum Temporal Lobe granulocyte superior frontal gyrus primary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding metal ion binding translation repressor activity RNA binding protein binding Cellular component cytoplasm perinuclear region of cytoplasm Biological process positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay regulation of translation cell migration epithelial cell migration negative regulation of translation posttranscriptional regulation of gene expression cerebellar neuron development tissue homeostasis regulation of cell growth Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 340719 332397 Ensembl ENSG00000188613 ENSMUSG00000072437 UniProt Q8WY41 Q80WY3 RefSeq (mRNA) NM_199461 NM_001009553 NM_178421 RefSeq (protein) NP_955631 NP_848508 Location (UCSC) Chr 10: 119.03 – 119.03 Mb Chr 19: 60.74 – 60.75 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Bonnomet A, Polette M, Strumane K, Gilles C, Dalstein V, Kileztky C, Berx G, van Roy F, Birembaut P, Nawrocki-Raby B (June 2008). "The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression". Oncogene. 27 (26): 3692–9. doi:10.1038/sj.onc.1211035. PMID 18223680. S2CID 12337713.
• Lu C, Xu M, Wang Y, Qin Y, Du G, Wu W, Han X, Ji C, Yang Y, Gu A, Xia Y, Song L, Wang S, Wang X (2013). "Genetic variants in meiotic program initiation pathway genes are associated with spermatogenic impairment in a Han Chinese population". PLOS ONE. 8 (1): e53443. Bibcode:2013PLoSO...853443L. doi:10.1371/journal.pone.0053443. PMC 3540065. PMID 23320086.
• Kusz-Zamelczyk K, Sajek M, Spik A, Glazar R, Jędrzejczak P, Latos-Bieleńska A, Kotecki M, Pawelczyk L, Jaruzelska J (March 2013). "Mutations of NANOS1, a human homologue of the Drosophila morphogen, are associated with a lack of germ cells in testes or severe oligo-astheno-teratozoospermia". Journal of Medical Genetics. 50 (3): 187–93. doi:10.1136/jmedgenet-2012-101230. PMID 23315541. S2CID 30126299.
• Ginter-Matuszewska B, Kusz K, Spik A, Grzeszkowiak D, Rembiszewska A, Kupryjanczyk J, Jaruzelska J (September 2011). "NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells". Histochemistry and Cell Biology. 136 (3): 279–87. doi:10.1007/s00418-011-0842-y. PMID 21800163. S2CID 13208261.
• Strumane K, Bonnomet A, Stove C, Vandenbroucke R, Nawrocki-Raby B, Bruyneel E, Mareel M, Birembaut P, Berx G, van Roy F (October 2006). "E-cadherin regulates human Nanos1, which interacts with p120ctn and induces tumor cell migration and invasion". Cancer Research. 66 (20): 10007–15. doi:10.1158/0008-5472.CAN-05-3096. PMID 17047063.
• Kurokawa H, Aoki Y, Nakamura S, Ebe Y, Kobayashi D, Tanaka M (April 2006). "Time-lapse analysis reveals different modes of primordial germ cell migration in the medaka Oryzias latipes". Development, Growth & Differentiation. 48 (3): 209–21. doi:10.1111/j.1440-169X.2006.00858.x. PMID 16573738. S2CID 25956579.
• Jaruzelska J, Kotecki M, Kusz K, Spik A, Firpo M, Reijo Pera RA (April 2003). "Conservation of a Pumilio-Nanos complex from Drosophila germ plasm to human germ cells". Development Genes and Evolution. 213 (3): 120–6. doi:10.1007/s00427-003-0303-2. PMID 12690449. S2CID 19186730.
• Ginter-Matuszewska B, Spik A, Rembiszewska A, Koyias C, Kupryjanczyk J, Jaruzelska J (March 2009). "The SNARE-associated component SNAPIN binds PUMILIO2 and NANOS1 proteins in human male germ cells". Molecular Human Reproduction. 15 (3): 173–9. doi:10.1093/molehr/gap004. PMID 19168546.
• Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (July 2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience. 3 (7): 661–9. doi:10.1038/76615. hdl:1842/742. PMID 10862698. S2CID 14392630.