Mir-675 microRNA precursor family

In molecular biology mir-675 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

mir-675
Identifiers
Symbolmir-675
RfamRF00897
miRBase familyMIPF0000365
Other data
RNA typemicroRNA
Domain(s)Eukaryota;
PDB structuresPDBe

Inhibition of cell proliferation

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miR-675 overexpression brings about reduced proliferation in a range of embryonic and extraembryonic stem cell lines. It has been found to be embedded in the first exon of the large intergenic non-coding RNA H19, which is responsible for limiting placental growth prior to birth. There is upregulation of the targets of miR-675 in placentas lacking H19; these include the insulin-like growth factor 1 receptor (IGF1R). Thus placentas lacking miR-675 continue to grow. It is possible that controlled miR-675 release from H19 may enable a rapid inhibition of cell proliferation in response to cellular stress or oncogenic signals.[1]

COL2A1 upregulation in Osteoarthritis

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miR-675 has been found to be upregulated in osteoarthritic cartilage, alongside H19.[2] Indeed, there is co-regulation of these two RNAs. The COL2A1 gene associated with osteoarthritis through altered expression levels compared with in normal tissue is upregulated by miR-675 overexpression. It has been proposed that miR-675 may modulate collagen type II levels via an unknown target molecule, and there is potential for a diagnostic metabolic balance indicator in osteoarthritis through this microRNA.

See also

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References

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  1. ^ Keniry A, Oxley D, Monnier P, Kyba M, Dandolo L, Smits G, Reik W (June 2012). "The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r". Nature Cell Biology. 14 (7): 659–65. doi:10.1038/ncb2521. PMC 3389517. PMID 22684254.
  2. ^ Steck E, Boeuf S, Gabler J, Werth N, Schnatzer P, Diederichs S, Richter W (October 2012). "Regulation of H19 and its encoded microRNA-675 in osteoarthritis and under anabolic and catabolic in vitro conditions". Journal of Molecular Medicine. 90 (10): 1185–95. doi:10.1007/s00109-012-0895-y. PMID 22527881. S2CID 14203960.

Further reading

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