In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408),[1] and in human (MI0000448, MI0000748).[2] miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma.[3] It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.[4]
| mir-130 microRNA precursor family | |
|---|---|
 Predicted secondary structure and sequence conservation of mir-130 | |
| Identifiers | |
| Symbol | mir-130 |
| Rfam | RF00258 |
| miRBase | MI0000448 |
| miRBase family | MIPF0000034 |
| Other data | |
| RNA type | Gene; miRNA |
| Domain(s) | Eukaryota |
| GO | GO:0035195 GO:0035068 |
| SO | SO:0001244 |
| PDB structures | PDBe |
References
edit- ^ Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. hdl:11858/00-001M-0000-0010-94EF-7. PMID 12007417. S2CID 7901788.
- ^ Houbaviy, HB; Murray MF; Sharp PA (2003). "Embryonic stem cell-specific MicroRNAs". Dev Cell. 5 (2): 351–358. doi:10.1016/S1534-5807(03)00227-2. PMID 12919684.
- ^ Kutay H, Bai S, Datta J, et al. (2006). "Downregulation of miR-122 in the rodent and human hepatocellular carcinomas". J. Cell. Biochem. 99 (3): 671–8. doi:10.1002/jcb.20982. PMC 3033198. PMID 16924677.
- ^ Escobar G, Moi D, Ranghetti A, et al. (Jan 2014). "Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression". Sci. Transl. Med. 6 (217): 217. doi:10.1126/scitranslmed.3006353. PMID 24382895. S2CID 8430299.
External links
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