Michael Locke may refer to:
- Michael Locke (biologist) (1929–2013), English-born Canadian biologist
- Michael Locke (stuntman) (born 1979), member of the Dirty Sanchez crew
- Michael K. Locke (1952–2014), American politician
- Michael Lok (c.1532–c.1621), English merchant and traveller
See also
edit- Michael Laucke (born 1947), Canadian guitarist