Mezhdurechensk (Russian: Междуреченск) is the name of several inhabited localities in Russia.
- Urban localities
- Mezhdurechensk, Kemerovo Oblast, a city in Kemerovo Oblast; administratively incorporated as a city under oblast jurisdiction
- Mezhdurechensk, Komi Republic, an urban-type settlement in Udorsky District of the Komi Republic
- Mezhdurechensk, Samara Oblast, an urban-type settlement in Syzransky District of Samara Oblast
- Rural localities