McN-481

McN-481^[1]
Names
	Other names McNeil 481; NSC-42268; 13M2B
Identifiers
CAS Number	3625-18-1;
3D model (JSmol)	Interactive image;
ChemSpider	18164;
PubChem CID	19251;
	InChI InChI=1S/C12H18N2O3/c1-5-12(8(4)6-7(2)3)9(15)13-11(17)14-10(12)16/h6,8H,5H2,1-4H3,(H2,13,14,15,16,17) Key: VELIJARCYHAWJO-UHFFFAOYSA-N;
	SMILES CCC1(C(=O)NC(=O)NC1=O)C(C)C=C(C)C;
Properties
Chemical formula	C12H18N2O3
Molar mass	238.287 g·mol−1
Hazards
	Lethal dose or concentration (LD, LC):
LD50 (median dose)	3.5 mg/kg (mice, intraperitoneal)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

McN-481 is a convulsant barbiturate. It is an unsaturated analog of diberal (DMBB).^[3]^[4]

References

^ Brown, DA; Quilliam, JP (October 1964). "The effects of some centrally acting drugs on ganglionic transmission in the cat". British Journal of Pharmacology and Chemotherapy. 23 (2): 241–56. doi:10.1111/j.1476-5381.1964.tb01583.x. PMC 1704089. PMID 19108183.
^ Jones, G. P.; Horn, E. (October 1986). "Conformations of barbiturates related to pentobarbitone. IV. Crystal structure of 5-ethyl,5-(1?,3?-dimethylbut-2?-enyl) barbituric acid". Journal of Crystallographic and Spectroscopic Research. 16 (5): 629–637. Bibcode:1986JCCry..16..629J. doi:10.1007/BF01181245.
^ ^a ^b Cain, C. K.; Kleis, John (February 1959). "5-Ethyl-5-(1,3-Dimethyi-2-Butenyl)Barbituric Acid, A Potent Central Nervous System Stimulant". Journal of Medicinal and Pharmaceutical Chemistry. 1 (1): 31–36. doi:10.1021/jm50002a003. PMID 13655027.
^ "Barbituric acid product". 26 March 1957.

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Names

Other names McNeil 481 NSC-42268 13M2B^[2]
Identifiers
CAS Number	3625-18-1
3D model (JSmol)	Interactive image
ChemSpider	18164
PubChem CID	19251
InChI InChI=1S/C12H18N2O3/c1-5-12(8(4)6-7(2)3)9(15)13-11(17)14-10(12)16/h6,8H,5H2,1-4H3,(H2,13,14,15,16,17) Key: VELIJARCYHAWJO-UHFFFAOYSA-N
SMILES CCC1(C(=O)NC(=O)NC1=O)C(C)C=C(C)C
Properties
Chemical formula	C₁₂H₁₈N₂O₃
Molar mass	238.287 g·mol⁻¹
Hazards
Lethal dose or concentration (LD, LC):
LD₅₀ (median dose)	3.5 mg/kg (mice, intraperitoneal)^[3]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references