Matrix metalloproteinase-17 (MMP-17) also known as membrane-type matrix metalloproteinase 4 (MT-MMP 4) is an enzyme that in humans is encoded by the MMP17 gene.[5][6]

MMP17
Identifiers
AliasesMMP17, MT4-MMP, MMP-17, MT4MMP, MTMMP4, matrix metallopeptidase 17
External IDsOMIM: 602285; MGI: 1346076; HomoloGene: 22669; GeneCards: MMP17; OMA:MMP17 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016155

NM_011846

RefSeq (protein)

NP_057239
NP_057239.4

NP_035976

Location (UCSC)Chr 12: 131.83 – 131.85 MbChr 5: 129.66 – 129.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. MMP17 and MMP25 are to this day the only known GPI-anchored membrane-type MMPs, opposite to the more common transmembrane MMPs. The protein activates MMP2 by cleavage.[6]

In melanocytic cells MMP17 gene expression may be regulated by MITF.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198598Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029436Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Pendas AM, Llano E, Lopez-Otin C (Feb 1999). "Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24". Genomics. 54 (3): 578–9. doi:10.1006/geno.1998.5564. PMID 9878265.
  6. ^ a b "Entrez Gene: MMP17 matrix metallopeptidase 17 (membrane-inserted)".
  7. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.

Further reading

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  • The MEROPS online database for peptidases and their inhibitors: M10.017