METTL2B

METTL2B
Identifiers
Aliases	METTL2B, METL, METTL2, METTL2A, PSENIP1, methyltransferase like 2B, methyltransferase 2B, methylcytidine
External IDs	OMIM: 607846; MGI: 1289171; HomoloGene: 130696; GeneCards: METTL2B; OMA:METTL2B - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,506,602 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	105,031,220 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; cerebellar vermis; ; islet of Langerhans; ; quadriceps femoris muscle; ; skeletal muscle tissue; ; gonad; ; endometrium; ; tonsil; ; stromal cell of endometrium; ; muscle of thigh;
	Top expressed in
	otic vesicle; ; hand; ; spermatocyte; ; tail of embryo; ; epiblast; ; Rostral migratory stream; ; abdominal wall; ; primitive streak; ; embryo; ; ventricular zone;
	More reference expression data
	More reference expression data
Orthologs
	55798
	52686
	ENSG00000165055
	ENSMUSG00000020691
	Q6P1Q9
	Q8BMK1
	NM_018396
	NM_172567
	NP_060866
	NP_766155
	Wikidata
View/Edit Human	View/Edit Mouse

Methyltransferase-like protein 2B is an enzyme that in humans is encoded by the METTL2B gene.^[5]^[6]

This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165055 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020691 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhang SX, Guo Y, Boulianne GL (Dec 2001). "Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins". Gene. 280 (1–2): 135–44. doi:10.1016/S0378-1119(01)00770-3. PMID 11738826.
^ ^a ^b "Entrez Gene: METTL2B methyltransferase like 2B".

Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage". Nature. 440 (7087): 1045–9. Bibcode:2006Natur.440.1045Z. doi:10.1038/nature04689. PMC 2610434. PMID 16625196.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165055 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020691 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11738826-5] Zhang SX, Guo Y, Boulianne GL (Dec 2001). "Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins". Gene. 280 (1–2): 135–44. doi:10.1016/S0378-1119(01)00770-3. PMID 11738826.

[entrez-6] "Entrez Gene: METTL2B methyltransferase like 2B".

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METTL2B

References

Further reading