MERS coronavirus EMC/2012 (MERS coronavirus Erasmus Medical Center/2012) is a strain of coronavirus isolated from the sputum of the first person to become infected with what was later named Middle East respiratory syndrome–related coronavirus (MERS-CoV), a virus that causes Middle East respiratory syndrome (MERS).[1][2][3][4]
| MERS coronavirus EMC/2012 | |
|---|---|
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| Middle East respiratory syndrome-related coronavirus particle envelope proteins immunolabeled with rabbit HCoV-EMC/2012 primary antibody and goat anti-rabbit 10 nm gold particles. | |
Virus classification 
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| (unranked): | Virus |
| Realm: | Riboviria |
| Kingdom: | Orthornavirae |
| Phylum: | Pisuviricota |
| Class: | Pisoniviricetes |
| Order: | Nidovirales |
| Family: | Coronaviridae |
| Genus: | Betacoronavirus |
| Subgenus: | Merbecovirus |
| Species: | |
| Strain: | MERS coronavirus EMC/2012
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| Synonyms | |
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Natural reservoir
editAn investigation of bat roosts in Bisha, the hometown of the index patient, by the Saudi Ministry of Health discovered an Egyptian tomb bat in a large roost close to the index patient's home. Phylogenetic analysis showed a 100% match between the virus isolated from the bat and MERS coronavirus EMC/2012 isolated from the index patient.[5]
Virology
editMERS coronavirus EMC/2012 is the sixth coronavirus known to infect humans and the first human virus within betacoronavirus lineage C. It is a new genotype which is related to bat coronaviruses, specifically an Egyptian tomb bat, and is not the same beta-CoV as the SARS-CoV, but is distantly related.[3][6]
See also
editReferences
edit- ^ Zaki, AM; van Boheemen, S; Bestebroer, TM; Osterhaus, AD; Fouchier, RA (2012). "Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia". N Engl J Med. 367 (19): 1814–20. doi:10.1056/nejmoa1211721. PMID 23075143.
- ^ Holmes, KV; Dominguez, SR (January 2013). "The new age of virus discovery: genomic analysis of a novel human betacoronavirus isolated from a fatal case of pneumonia". mBio. 4 (1): e00548–12. doi:10.1128/mBio.00548-12. PMC 3546555. PMID 23300251.
- ^ a b Van Boheemen, S; de Graaf, M; Lauber, C; Bestebroer, TM; Raj, VS; Zaki, AM; Osterhaus, AD; Haagmans, BL; Gorbalenya, AE; Snijder, EJ; Fouchier, RA (November 2012). "Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans". mBio. 3 (6): 6. doi:10.1128/mBio.00473-12. PMC 3509437. PMID 23170002.
- ^ Chan, JF; Li, KS; To, KK; Cheng, VC; Chen, H; Yuen, KY (25 March 2013). "Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?". J Infect. 65 (6): 477–89. doi:10.1016/j.jinf.2012.10.002. PMC 7112628. PMID 23072791.
- ^ Memish, Ziad A.; Mishra, Nischay; Olival, Kevin J.; Fagbo, Shamsudeen F.; Kapoor, Vishal; Epstein, Jonathan H.; Alhakeem, Rafat; Durosinloun, Abdulkareem; Al Asmari, Mushabab; Islam, Ariful; Kapoor, Amit; Briese, Thomas; Daszak, Peter; Al Rabeeah, Abdullah A.; Lipkin, W. Ian (2013). "Middle East Respiratory Syndrome Coronavirus in Bats, Saudi Arabia". Emerging Infectious Diseases. 19 (11): 1819–23. doi:10.3201/eid1911.131172. PMC 3837665. PMID 24206838.
- ^ Chan, JF; Li, KS; To, KK; Cheng, VC; Chen, H; Yuen, KY (December 2012). "Is the discovery of the novel human betacoronavirus 2c EMC/2012 (HCoV-EMC) the beginning of another SARS-like pandemic?". J Infect. 65 (6): 477–89. doi:10.1016/j.jinf.2012.10.002. PMC 7112628. PMID 23072791.