MEIS2

Homeobox protein Meis2 is a protein that in humans is encoded by the MEIS2 gene.

MEIS2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3K2A, 5BNG, 4XRM
Identifiers
Aliases	MEIS2, HsT18361, MRG1, Meis homeobox 2, CPCMR
External IDs	OMIM: 601740; MGI: 108564; HomoloGene: 7846; GeneCards: MEIS2; OMA:MEIS2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q14 Start 36,889,204 bp End 37,101,299 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 E4- E5|2 58.28 cM Start 115,693,545 bp End 115,896,320 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence pancreatic ductal cell parotid gland palpebral conjunctiva mucosa of paranasal sinus tail of epididymis external globus pallidus parietal pleura body of uterus Top expressed in Rostral migratory stream vas deferens dorsal striatum genital tubercle ventricular zone ganglionic eminence olfactory bulb olfactory tubercle medial ganglionic eminence nucleus accumbens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding transcription coregulator activity RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA binding Cellular component cytoplasm perinuclear region of cytoplasm nucleus Biological process eye development visual learning regulation of transcription, DNA-templated response to mechanical stimulus negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription, DNA-templated multicellular organism development pancreas development response to growth factor negative regulation of myeloid cell differentiation positive regulation of transcription by RNA polymerase II positive regulation of mitotic cell cycle positive regulation of cardiac muscle myoblast proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4212 17536 Ensembl ENSG00000134138 ENSMUSG00000027210 UniProt O14770 P97367 RefSeq (mRNA) NM_001220482 NM_002399 NM_020149 NM_170674 NM_170675 NM_170676 NM_170677 NM_172315 NM_172316 NM_001136072 NM_001159567 NM_001159568 NM_001159569 NM_001159570 NM_010825 NM_001346036 NM_001346038 NM_001346041 NM_001346044 NM_001346045 NM_001346047 NM_001346053 NM_001346055 NM_001346056 RefSeq (protein) NP_001207411 NP_002390 NP_733774 NP_733775 NP_733776 NP_733777 NP_758526 NP_758527 NP_001129544 NP_001153039 NP_001153040 NP_001153041 NP_001153042 NP_001332965 NP_001332967 NP_001332970 NP_001332973 NP_001332974 NP_001332976 NP_001332982 NP_001332984 NP_001332985 NP_034955 Location (UCSC) Chr 15: 36.89 – 37.1 Mb Chr 2: 115.69 – 115.9 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a homeobox protein belonging to the TALE ('three amino acid loop extension') family of homeodomain-containing proteins. TALE homeobox proteins are highly conserved transcription regulators, and several members have been shown to be essential contributors to developmental programs. Multiple transcript variants encoding distinct isoforms have been described for this gene.

Further reading

• Hui H, Perfetti R (2002). "Pancreas duodenum homeobox-1 regulates pancreas development during embryogenesis and islet cell function in adulthood". Eur. J. Endocrinol. 146 (2): 129–41. doi:10.1530/eje.0.1460129. PMID 11834421.
• Steelman S, Moskow JJ, Muzynski K, et al. (1997). "Identification of a conserved family of Meis1-related homeobox genes". Genome Res. 7 (2): 142–56. doi:10.1101/gr.7.2.142. PMID 9049632.
• Capdevila J, Tsukui T, Rodríquez Esteban C, et al. (2000). "Control of vertebrate limb outgrowth by the proximal factor Meis2 and distal antagonism of BMPs by Gremlin". Mol. Cell. 4 (5): 839–49. doi:10.1016/S1097-2765(00)80393-7. PMID 10619030.
• Yang Y, Hwang CK, D'Souza UM, et al. (2000). "Three-amino acid extension loop homeodomain proteins Meis2 and TGIF differentially regulate transcription". J. Biol. Chem. 275 (27): 20734–41. doi:10.1074/jbc.M908382199. PMID 10764806.
• Liu Y, MacDonald RJ, Swift GH (2001). "DNA binding and transcriptional activation by a PDX1.PBX1b.MEIS2b trimer and cooperation with a pancreas-specific basic helix-loop-helix complex". J. Biol. Chem. 276 (21): 17985–93. doi:10.1074/jbc.M100678200. PMID 11279116.
• Fujino T, Yamazaki Y, Largaespada DA, et al. (2001). "Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes". Exp. Hematol. 29 (7): 856–63. doi:10.1016/S0301-472X(01)00655-5. PMID 11438208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Dintilhac A, Bihan R, Guerrier D, et al. (2004). "A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical' Hoxa9 protein during embryogenesis". Gene Expr. Patterns. 4 (2): 215–22. doi:10.1016/j.modgep.2003.08.006. PMID 15161102.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• MEIS2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.