MCRS1

Microspherule protein 1 is a protein that in humans is encoded by the MCRS1 gene.

MCRS1
Identifiers
Aliases	MCRS1, ICP22BP, INO80Q, MCRS2, MSP58, P78, microspherule protein 1
External IDs	OMIM: 609504; MGI: 1858420; HomoloGene: 4622; GeneCards: MCRS1; OMA:MCRS1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.12 Start 49,556,544 bp End 49,568,145 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 F1 Start 99,140,698 bp End 99,149,842 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart granulocyte left ventricle right auricle right lobe of thyroid gland left lobe of thyroid gland mucosa of transverse colon right frontal lobe body of stomach left testis Top expressed in Mesencephalon neural tube ganglionic eminence spermatocyte ventricular zone epiblast spermatid neural layer of retina limb muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function poly(U) RNA binding histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K5 specific) poly(G) binding protein binding histone acetyltransferase activity (H4-K16 specific) telomerase inhibitor activity G-quadruplex RNA binding Cellular component nucleoplasm nucleolus histone acetyltransferase complex nucleus dendrite cytoplasm polysome perikaryon endoplasmic reticulum Ino80 complex MLL1 complex NSL complex Biological process positive regulation of protein localization to nucleolus DNA recombination regulation of transcription, DNA-templated negative regulation of telomerase activity transcription, DNA-templated histone H4-K5 acetylation cellular response to DNA damage stimulus negative regulation of telomere maintenance via telomere lengthening histone H4-K16 acetylation histone H4-K8 acetylation DNA repair protein deubiquitination chromatin organization positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10445 51812 Ensembl ENSG00000187778 ENSMUSG00000037570 UniProt Q96EZ8 Q99L90 RefSeq (mRNA) NM_001012300 NM_001278341 NM_006337 NM_001164156 NM_016766 RefSeq (protein) NP_001012300 NP_001265270 NP_006328 NP_001157628 NP_058046 Location (UCSC) Chr 12: 49.56 – 49.57 Mb Chr 15: 99.14 – 99.15 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

MCRS1 has been shown to interact with PHC2, Death associated protein 6, NOL1, PINX1 and Telomerase reverse transcriptase.

Further reading

• Lin DY, Shih HM (Jul 2002). "Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration". The Journal of Biological Chemistry. 277 (28): 25446–56. doi:10.1074/jbc.M200633200. PMID 11948183.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (Jan 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
• Song H, Li Y, Chen G, Xing Z, Zhao J, Yokoyama KK, Li T, Zhao M (Apr 2004). "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length". Biochemical and Biophysical Research Communications. 316 (4): 1116–23. doi:10.1016/j.bbrc.2004.02.166. PMID 15044100.
• Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
• Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP (Nov 2004). "Phosphoproteomic analysis of the developing mouse brain". Molecular & Cellular Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Shimono K, Shimono Y, Shimokata K, Ishiguro N, Takahashi M (Nov 2005). "Microspherule protein 1, Mi-2beta, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription". The Journal of Biological Chemistry. 280 (47): 39436–47. doi:10.1074/jbc.M507356200. PMID 16186106.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Hirohashi Y, Wang Q, Liu Q, Du X, Zhang H, Sato N, Greene MI (Aug 2006). "p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability". Oncogene. 25 (35): 4937–46. doi:10.1038/sj.onc.1209500. PMID 16547491.
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (Apr 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Davidovic L, Bechara E, Gravel M, Jaglin XH, Tremblay S, Sik A, Bardoni B, Khandjian EW (May 2006). "The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons". Human Molecular Genetics. 15 (9): 1525–38. doi:10.1093/hmg/ddl074. PMID 16571602.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Du X, Wang Q, Hirohashi Y, Greene MI (Dec 2006). "DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription". Experimental and Molecular Pathology. 81 (3): 184–90. doi:10.1016/j.yexmp.2006.07.008. PMID 17014843.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Zhang J, Liu J, Li X, Li F, Wang L, Zhang J, Liu X, Shen L, Liu N, Deng Y, Yang A, Han H, Zhao M, Yao L (Jan 2007). "The physical and functional interaction of NDRG2 with MSP58 in cells". Biochemical and Biophysical Research Communications. 352 (1): 6–11. doi:10.1016/j.bbrc.2006.10.141. PMID 17109818.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.