MAL2 (gene)

Protein MAL2 is a protein that in humans is encoded by the MAL2 gene.

MAL2
Identifiers
Aliases	MAL2, mal, T-cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2 (gene/pseudogene), mal, T cell differentiation protein 2
External IDs	OMIM: 609684; MGI: 2146021; HomoloGene: 14167; GeneCards: MAL2; OMA:MAL2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q24.12 Start 119,165,034 bp End 119,245,673 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 D1 Start 54,434,588 bp End 54,466,243 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm oral cavity mucosa of pharynx nasal epithelium amniotic fluid palpebral conjunctiva human penis gums mucosa of colon mucosa of sigmoid colon Top expressed in subiculum right lung lobe epithelium of stomach Region I of hippocampus proper primary motor cortex mucous cell of stomach cingulate gyrus conjunctival fornix anterior amygdaloid area prefrontal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding structural constituent of myelin sheath Cellular component cytoplasm perinuclear region of cytoplasm plasma membrane extracellular exosome apical plasma membrane membrane endomembrane system membrane raft integral component of membrane integral component of synaptic vesicle membrane hippocampal mossy fiber to CA3 synapse glutamatergic synapse Biological process transcytosis membrane raft polarization protein localization myelination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114569 105853 Ensembl ENSG00000147676 ENSMUSG00000024479 UniProt Q969L2 Q8BI08 RefSeq (mRNA) NM_052886 NM_178920 RefSeq (protein) NP_443118 NP_443118.1 NP_849251 Location (UCSC) Chr 8: 119.17 – 119.25 Mb Chr 15: 54.43 – 54.47 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a multispan transmembrane protein belonging to the MAL proteolipid family. The protein is a component of lipid rafts and, in polarized cells, it primarily localizes to endosomal structures beneath the apical membrane. It is required for transcytosis, an intracellular transport pathway used to deliver membrane-bound proteins and exogenous cargos from the basolateral to the apical surface.

Interactions

MAL2 (gene) has been shown to interact with TPD52.

Further reading

• Marazuela M, Alonso MA (2004). "Expression of MAL and MAL2, two elements of the protein machinery for raft-mediated transport, in normal and neoplastic human tissue". Histol. Histopathol. 19 (3): 925–33. PMID 15168355.
• Rohan S, Tu JJ, Kao J, et al. (2007). "Gene expression profiling separates chromophobe renal cell carcinoma from oncocytoma and identifies vesicular transport and cell junction proteins as differentially expressed genes". Clin. Cancer Res. 12 (23): 6937–45. doi:10.1158/1078-0432.CCR-06-1268. PMID 17145811.
• Barbaric D, Byth K, Dalla-Pozza L, Byrne JA (2007). "Expression of tumor protein D52-like genes in childhood leukemia at diagnosis: clinical and sample considerations". Leuk. Res. 30 (11): 1355–63. doi:10.1016/j.leukres.2006.03.009. PMID 16620967.
• de Marco MC, Puertollano R, Martínez-Menárguez JA, Alonso MA (2006). "Dynamics of MAL2 during glycosylphosphatidylinositol-anchored protein transcytotic transport to the apical surface of hepatoma HepG2 cells". Traffic. 7 (1): 61–73. doi:10.1111/j.1600-0854.2005.00361.x. PMID 16445687. S2CID 44752098.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Llorente A, de Marco MC, Alonso MA (2005). "Caveolin-1 and MAL are located on prostasomes secreted by the prostate cancer PC-3 cell line". J. Cell Sci. 117 (Pt 22): 5343–51. doi:10.1242/jcs.01420. PMID 15466889.
• Marazuela M, Acevedo A, García-López MA, et al. (2004). "Expression of MAL2, an integral protein component of the machinery for basolateral-to-apical transcytosis, in human epithelia". J. Histochem. Cytochem. 52 (2): 243–52. doi:10.1177/002215540405200212. PMID 14729876.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Marazuela M, Martín-Belmonte F, García-López MA, et al. (2004). "Expression and distribution of MAL2, an essential element of the machinery for basolateral-to-apical transcytosis, in human thyroid epithelial cells". Endocrinology. 145 (2): 1011–6. doi:10.1210/en.2003-0652. PMID 14576188.
• Boutros R, Bailey AM, Wilson SH, Byrne JA (2003). "Alternative splicing as a mechanism for regulating 14-3-3 binding: interactions between hD53 (TPD52L1) and 14-3-3 proteins". J. Mol. Biol. 332 (3): 675–87. doi:10.1016/S0022-2836(03)00944-6. PMID 12963375.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• de Marco MC, Martín-Belmonte F, Kremer L, et al. (2002). "MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells". J. Cell Biol. 159 (1): 37–44. doi:10.1083/jcb.200206033. PMC 2173496. PMID 12370246.