Lobo, in comics, may refer to:
- Lobo (DC Comics), the alien bounty hunter
- Lobo (Dell Comics), the African-American comic book character
- Lobo the Duck, an Amalgam Comics fusion of DC's Lobo and Marvel's Howard the Duck
It may also refer to:
- Lobo Brothers, two Marvel Comics werewolves
- Maximus Lobo, a Marvel Comics character