Lithium aspartate

Lithium aspartate
Clinical data
AHFS/Drugs.com	Monograph
Routes of; administration	Oral
Legal status
Legal status	In general: Over-the-counter (OTC);
Identifiers
CAS Number	70962-88-8 ;
PubChem CID	71587253;
ChemSpider	34994320 ;
UNII	L2N7Z24B30;
CompTox Dashboard (EPA)	DTXSID001319264 ;
Chemical and physical data
Formula	C4H6LiNO4
Molar mass	139.04 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [Li+].N[C@@H](CC(O)=O)C([O-])=O;
	InChI InChI=InChI=1S/C4H7NO4.Li/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H,6,7)(H,8,9);/q;+1/p-1/t2-;/m0./s1 ; Key:NFNOWBZQMRFQDG-DKWTVANSSA-M ;

Lithium aspartate (C₄H₆LiNO₄) is a salt of aspartic acid and lithium. It is sometimes marketed as a dietary supplement used in small doses to treat certain medical conditions; however, there are no systematic reviews supporting the efficacy, or safety of lithium aspartate and it is not approved by the U.S. Food and Drug Administration (FDA) for the treatment of any medical condition. Published research on lithium aspartate is sparse.^[1]^[2]^[3]

References

^ Müller-Oerlinghausen B, Imiela M (June 1986). "Is lithium aspartate at low serum levels more effective than the usual lithium salts?". Nervenarzt. 57 (6): 370–3. PMID 3736729.
^ Olbrich R, Watzl H, Völter M, Siedow H (March 1991). "Lithium in the treatment of chronic alcoholic patients with brain damage--a controlled study". Nervenarzt. 62 (3): 182–6. PMID 2052117.
^ Daunderer M (September 1982). "Lithium aspartate in drug dependence". Fortschr. Med. 100 (33): 1500–2. PMID 7129311.
^ Chen PE, Geballe MT, Stansfeld PJ, Johnston AR, Yuan H, Jacob AL, Snyder JP, Traynelis SF, Wyllie DJ (May 2005). "Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling". Molecular Pharmacology. 67 (5): 1470–84. doi:10.1124/mol.104.008185. PMID 15703381. S2CID 13505187.

Lithium – The Misunderstood Mineral Part 1 article on lithium compounds by Jonathan Wright, M.D.

Clinical data

AHFS/Drugs.com	Monograph
Routes of administration	Oral
Legal status
Legal status	In general: Over-the-counter (OTC)
Identifiers
CAS Number	70962-88-8^Y
PubChem CID	71587253
ChemSpider	34994320^N
UNII	L2N7Z24B30
CompTox Dashboard (EPA)	DTXSID001319264
Chemical and physical data
Formula	C₄H₆LiNO₄
Molar mass	139.04 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES [Li+].N[C@@H](CC(O)=O)C([O-])=O
InChI InChI=InChI=1S/C4H7NO4.Li/c5-2(4(8)9)1-3(6)7;/h2H,1,5H2,(H,6,7)(H,8,9);/q;+1/p-1/t2-;/m0./s1^N Key:NFNOWBZQMRFQDG-DKWTVANSSA-M^N