This is a list of the Spanish PROMUSICAE Top 20 physical Singles number-ones of 2006.[1][2]
| Issue Date | Song | Artist |
|---|---|---|
| 1 January | "Hung Up" | Madonna |
| 8 January | ||
| 15 January | ||
| 22 January | ||
| 29 January | "Rutinas" | Chenoa |
| 5 February | "First Day of My Life" | Melanie C |
| 12 February | ||
| 19 February | "Llámalo Perdón" | Estirpe |
| 26 February | "Thriller" | Michael Jackson |
| 5 March | "Sorry" | Madonna |
| 12 March | "Rock with You" | Michael Jackson |
| 19 March | "Billie Jean" | |
| 26 March | "Beat It" | |
| 2 April | "Bad" | |
| 9 April | "The Way You Make Me Feel" | |
| 16 April | "Dirty Diana" | |
| 23 April | "Smooth Criminal" | |
| 30 April | "Leave Me Alone" | |
| 7 May | "Vivir Para Contarlo" | Violadores Del Verso |
| 14 May | ||
| 21 May | ||
| 28 May | "Jam" | Michael Jackson |
| 4 June | "Heal the World" | |
| 11 June | "You Are Not Alone" | |
| 18 June | "Earth Song" | |
| 25 June | "Get Together" | Madonna |
| 2 July | "Stranger in Moscow" | Michael Jackson |
| 9 July | "Blood on the Dance Floor" | |
| 16 July | ||
| 23 July | "Vivir Para Contarlo" | Violadores Del Verso |
| 30 July | "Summerlove" | David Tavaré and U-gene |
| 6 August | "Vivir Para Contarlo" | Violadores Del Verso |
| 13 August | ||
| 20 August | "The Reincarnation of Benjamin Breeg" | Iron Maiden |
| 27 August | ||
| 3 September | ||
| 10 September | "Volveremos (himno Eventual Del Real Oviedo)" | Melendi |
| 17 September | ||
| 24 September | "Let Me Out" | Dover |
| 1 October | ||
| 8 October | "Criticar Por Criticar" | Fangoria |
| 15 October | ||
| 22 October | ||
| 29 October | "Por La Noche" | Mala Rodríguez |
| 5 November | "Martyr" | Depeche Mode |
| 12 November | "The Saints Are Coming" | U2 and Green Day |
| 19 November | ||
| 26 November | ||
| 3 December | ||
| 10 December | "Al Final De La Palmera" | Rafa González-Serna |
| 17 December | ||
| 24 December | ||
| 31 December |