Lim homeobox 9

LIM homeobox 9 is a protein that in humans is encoded by the LHX9 gene.

LHX9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DMQ
Identifiers
Aliases	LHX9, LIM homeobox 9
External IDs	OMIM: 606066; MGI: 1316721; HomoloGene: 7816; GeneCards: LHX9; OMA:LHX9 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q31.3 Start 197,911,902 bp End 197,935,478 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E4 Start 138,825,186 bp End 138,848,577 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium testicle left ovary right ovary stromal cell of endometrium ganglionic eminence gonad tendon of biceps brachii right coronary artery buccal mucosa cell Top expressed in hand habenula Gonadal ridge fossa coelomic epithelium pineal gland abdominal wall medial dorsal nucleus foot inferior colliculi More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding protein binding transcription corepressor activity metal ion binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus Biological process cell population proliferation male gonad development negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated female gonad development gonad morphogenesis dorsal spinal cord interneuron anterior axon guidance regulation of transcription by RNA polymerase II neuron differentiation positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56956 16876 Ensembl ENSG00000143355 ENSMUSG00000019230 UniProt Q9NQ69 Q9WUH2 RefSeq (mRNA) NM_001014434 NM_020204 NM_001370213 NM_001025565 NM_001042577 NM_010714 RefSeq (protein) NP_001014434 NP_064589 NP_001357142 NP_001020736 NP_001036042 NP_034844 Location (UCSC) Chr 1: 197.91 – 197.94 Mb Chr 1: 138.83 – 138.85 Mb PubMed search
Wikidata
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Function

This gene encodes a member of the LIM homeobox gene family of developmentally expressed transcription factors. The encoded protein contains a homeodomain and two cysteine-rich zinc-binding LIM domains involved in protein-protein interactions. The protein is highly similar to a mouse protein that causes gonadal agenesis when inactivated, suggesting a role in gonadal development. Alternative splicing results in multiple transcript variants.

Further reading

• Avraham O, Hadas Y, Vald L, Zisman S, Schejter A, Visel A, Klar A (2009). "Transcriptional control of axonal guidance and sorting in dorsal interneurons by the Lim-HD proteins Lhx9 and Lhx1". Neural Dev. 4: 21. doi:10.1186/1749-8104-4-21. PMC 2704203. PMID 19545367.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.