Levodropropizine

Levodropropizine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	R05DB27 (WHO) ;
Pharmacokinetic data
Protein binding	11-14%
Excretion	83% via urine within 96 h
Identifiers
	IUPAC name (2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol;
CAS Number	99291-25-5 ;
PubChem CID	65859;
DrugBank	DB12472 ;
ChemSpider	59270 ;
UNII	3O31P6T4G3;
KEGG	D08119 ;
ChEBI	CHEBI:82722 ;
CompTox Dashboard (EPA)	DTXSID8023210 ;
ECHA InfoCard	100.167.719
Chemical and physical data
Formula	C13H20N2O2
Molar mass	236.315 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O[C@@H](CN2CCN(c1ccccc1)CC2)CO;
	InChI InChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1 ; Key:PTVWPYVOOKLBCG-ZDUSSCGKSA-N ;
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Levodropropizine is a cough suppressant. It is the levo isomer of dropropizine. It acts as a peripheral antitussive, with no action in the central nervous system.^[1] It does not cause side effects such as constipation or respiratory depression which can be produced by opioid antitussives such as codeine and its derivatives.

In September 2021, Korea United Pharm file lawsuits against 15 drug manufacturers as patent infringement protection for its 2017 registered antitussive drug Levotics CR Tab. (levodropropizine). The cases are anchored on violation of its patent for "Method for Preparing Sustained-Release Tablets Containing Levodropropizine."^[2] In September 2023, KUP signed a five-year $52.1 million contract with MCQ, a Thai-based pharmaceutical company, for supply of its mucoactive drug, Levotics CR Tab (levodropropizine).^[3]

External links

Levodropropizine - Monthly Index of Medical Specialities

References

^ De Blasio F, Dicpinigaitis PV, Rubin BK, De Danieli G, Lanata L, Zanasi A (January 2012). "An observational study on cough in children: epidemiology, impact on quality of sleep and treatment outcome". Cough. 8 (1): 1. doi:10.1186/1745-9974-8-1. PMC 3274450. PMID 22269875.
^ Chan-hyuk, Kim (September 9, 2021). "Korea United Pharm sues 15 drugmakers to protect cough suppressant's patent". Korea Biomedical Review. Retrieved July 29, 2024.
^ "Korea United Pharm to supply mucoactive drugs worth $52 million to Thailand". Korea Biomedical Review. September 9, 2023. Retrieved July 29, 2024.

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[1] De Blasio F, Dicpinigaitis PV, Rubin BK, De Danieli G, Lanata L, Zanasi A (January 2012). "An observational study on cough in children: epidemiology, impact on quality of sleep and treatment outcome". Cough. 8 (1): 1. doi:10.1186/1745-9974-8-1. PMC 3274450. PMID 22269875.

[2] Chan-hyuk, Kim (September 9, 2021). "Korea United Pharm sues 15 drugmakers to protect cough suppressant's patent". Korea Biomedical Review. Retrieved July 29, 2024.

[3] "Korea United Pharm to supply mucoactive drugs worth $52 million to Thailand". Korea Biomedical Review. September 9, 2023. Retrieved July 29, 2024.

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