Leighton is a given name. Notable people with the name include:
- Leighton Baines (born 1984), English footballer
- Leighton Clarkson (born 2001), English footballer
- Leighton Dye (1901–1977), American hurdler
- Leighton A. Hope (1921–1998), New York politician
- Leighton James (born 1953), Welsh footballer
- Leighton Meester (born 1986), American actress, singer and model
- Leighton Phillips (born 1949), Welsh footballer
- Leighton Rees (1940–2003), Welsh dart player
- Leighton Schubert (born c. 1982), Texas politician
- Leighton Vander Esch (born 1997), American football player
- Leighton Walsh (born 1982), DJ better known by the stage name Walshy Fire
- Leighton Sekemoto, famous sim from The Sims 3-franchise