Layilin

Layilin is a protein that in humans is encoded by the LAYN gene.

LAYN
Identifiers
Aliases	LAYN, Layilin
External IDs	MGI: 2685357; HomoloGene: 18716; GeneCards: LAYN; OMA:LAYN - orthologs
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.1 Start 111,540,280 bp End 111,561,745 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.3 Start 50,965,940 bp End 50,988,394 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua stromal cell of endometrium amniotic fluid ascending aorta pancreatic epithelial cell Descending thoracic aorta muscle layer of sigmoid colon smooth muscle tissue urethra left ovary Top expressed in aortic valve ascending aorta endothelial cell of lymphatic vessel embryo embryo facial motor nucleus lens blood supraoptic nucleus cumulus cell More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 143903 244864 Ensembl ENSG00000204381 ENSMUSG00000060594 UniProt Q6UX15 Q8C351 RefSeq (mRNA) NM_001258390 NM_001258391 NM_178834 NM_001318799 NM_001033534 RefSeq (protein) NP_001245319 NP_001245320 NP_001305728 NP_849156 NP_001028706 Location (UCSC) Chr 11: 111.54 – 111.56 Mb Chr 9: 50.97 – 50.99 Mb PubMed search
Wikidata
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Medical Relevance

A study has shown that Layilin is upregulated in tumor infiltrating CD8+ Cytotoxic T cells of patients with liver cancer.

Further reading

• Bono P, Rubin K, Higgins JM, Hynes RO (2001). "Layilin, a novel integral membrane protein, is a hyaluronan receptor". Mol. Biol. Cell. 12 (4): 891–900. doi:10.1091/mbc.12.4.891. PMC 32274. PMID 11294894.
• Borowsky ML, Hynes RO (1998). "Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles". J. Cell Biol. 143 (2): 429–42. doi:10.1083/jcb.143.2.429. PMC 2132847. PMID 9786953.
• Forteza RM, Casalino-Matsuda SM, Falcon NS, Valencia Gattas M, Monzon ME (2012). "Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin". J. Biol. Chem. 287 (50): 42288–98. doi:10.1074/jbc.M112.387795. PMC 3516772. PMID 23048036.
• Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO (2005). "Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin". Exp. Cell Res. 308 (1): 177–87. doi:10.1016/j.yexcr.2005.04.017. PMID 15913605.