LP-211

LP-211
Identifiers
	IUPAC name N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;
CAS Number	1052147-86-0;
PubChem CID	25107716;
ChemSpider	23343345 ;
UNII	NCS2VAH93R;
CompTox Dashboard (EPA)	DTXSID201029790 ;
Chemical and physical data
Formula	C30H34N4O
Molar mass	466.629 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N#Cc3ccc(cc3)CNC(=O)CCCCCN(CC2)CCN2c1ccccc1-c4ccccc4;
	InChI InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35) ; Key:BQEDZLDNNBDKDS-UHFFFAOYSA-N ;
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LP-211 is a drug which acts as a potent and selective agonist at the 5HT₇ serotonin receptor, with better brain penetration than older 5-HT₇ agonists in the same series, and similar effects in animals.^[1]^[2]

References

^ Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R (August 2010). "LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor". Neuroscience Letters. 481 (1): 12–6. doi:10.1016/j.neulet.2010.06.036. PMC 2910240. PMID 20600619.
^ Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews. 15 (4): 269–81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634.

[pmid20600619-1] Hedlund PB, Leopoldo M, Caccia S, Sarkisyan G, Fracasso C, Martelli G, Lacivita E, Berardi F, Perrone R (August 2010). "LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor". Neuroscience Letters. 481 (1): 12–6. doi:10.1016/j.neulet.2010.06.036. PMC 2910240. PMID 20600619.

[pmid21459634-2] Monti JM (August 2011). "Serotonin control of sleep-wake behavior". Sleep Medicine Reviews. 15 (4): 269–81. doi:10.1016/j.smrv.2010.11.003. PMID 21459634.

[1]

[2]

Identifiers

IUPAC name N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
CAS Number	1052147-86-0
PubChem CID	25107716
ChemSpider	23343345^N
UNII	NCS2VAH93R
CompTox Dashboard (EPA)	DTXSID201029790
Chemical and physical data
Formula	C₃₀H₃₄N₄O
Molar mass	466.629 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES N#Cc3ccc(cc3)CNC(=O)CCCCCN(CC2)CCN2c1ccccc1-c4ccccc4
InChI InChI=1S/C30H34N4O/c31-23-25-14-16-26(17-15-25)24-32-30(35)13-5-2-8-18-33-19-21-34(22-20-33)29-12-7-6-11-28(29)27-9-3-1-4-10-27/h1,3-4,6-7,9-12,14-17H,2,5,8,13,18-22,24H2,(H,32,35)^N Key:BQEDZLDNNBDKDS-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

LP-211

See also

References