LHFP

Lipoma HMGIC fusion partner is a protein that in humans is encoded by the LHFP gene.

LHFPL6
Identifiers
Aliases	LHFPL6, LHFP, lipoma HMGIC fusion partner, LHFPL tetraspan subfamily member 6
External IDs	OMIM: 606710; MGI: 1920048; HomoloGene: 4223; GeneCards: LHFPL6; OMA:LHFPL6 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) Band 13q13.3-q14.11 Start 39,209,116 bp End 39,603,528 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 C Start 52,948,949 bp End 53,169,100 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava Achilles tendon synovial joint right coronary artery superficial temporal artery saphenous vein tibial nerve cerebellar vermis left coronary artery Descending thoracic aorta Top expressed in ascending aorta aortic valve molar endothelial cell of lymphatic vessel right lung hand calvaria right lung lobe body of femur sciatic nerve More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 10186 108927 Ensembl ENSG00000183722 ENSMUSG00000048332 UniProt Q9Y693 Q8BM86 RefSeq (mRNA) NM_005780 NM_175386 RefSeq (protein) NP_005771 NP_780595 Location (UCSC) Chr 13: 39.21 – 39.6 Mb Chr 3: 52.95 – 53.17 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the lipoma HMGIC fusion partner (LHFP) gene family, which is a subset of the superfamily of tetraspan transmembrane protein encoding genes. This gene is fused to a high-mobility group gene in a translocation-associated lipoma. Mutations in another LHFP-like gene (LHFPL1, LHFPL2) result in deafness in humans and mice. Alternatively spliced transcript variants have been found; however, their full-length nature is not known.

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Longo-Guess CM, Gagnon LH, Cook SA, et al. (2005). "A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice". Proc. Natl. Acad. Sci. U.S.A. 102 (22): 7894–9. Bibcode:2005PNAS..102.7894L. doi:10.1073/pnas.0500760102. PMC 1142366. PMID 15905332.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288. PMID 15057823.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.

External links

• LHFP human gene location in the UCSC Genome Browser.
• LHFP human gene details in the UCSC Genome Browser.