KDM5D

Lysine-specific demethylase 5D is an enzyme that in humans is encoded by the KDM5D gene. KDM5D belongs to the alpha-ketoglutarate-dependent hydroxylases superfamily.

KDM5D
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E6R, 2YQE
Identifiers
Aliases	KDM5D, HY, HYA, JARID1D, SMCY, lysine demethylase 5D
External IDs	OMIM: 426000; MGI: 99780; HomoloGene: 55838; GeneCards: KDM5D; OMA:KDM5D - orthologs
Gene location (Human) Chr. Y chromosome (human) Band Yq11.223 Start 19,703,865 bp End 19,744,939 bp
Gene location (Mouse) Chr. Y chromosome (mouse) Band Y|Ypter Start 897,788 bp End 956,786 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart rectum right lung prostate skin of thigh mucosa of transverse colon urethra trabecular bone gonad Brodmann area 9 Top expressed in tail of embryo left lung lobe internal carotid artery external carotid artery female urethra granulocyte male urethra vas deferens triceps brachii muscle epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone H3-methyl-lysine-4 demethylase activity DNA binding oxidoreductase activity dioxygenase activity metal ion binding histone demethylase activity androgen receptor binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific chromatin binding histone H3-tri/di/monomethyl-lysine-4 demethylase activity methylated histone binding Cellular component nucleus nucleoplasm fibrillar center cellular component histone methyltransferase complex Biological process histone H3-K4 demethylation T cell antigen processing and presentation transcription, DNA-templated regulation of transcription, DNA-templated regulation of androgen receptor signaling pathway chromatin organization regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II histone H3-K4 demethylation, trimethyl-H3-K4-specific chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8284 20592 Ensembl ENSG00000012817 ENSMUSG00000056673 UniProt Q9BY66 Q62240 RefSeq (mRNA) NM_001146705 NM_001146706 NM_004653 NM_011419 RefSeq (protein) NP_001140177 NP_001140178 NP_004644 NP_035549 Location (UCSC) Chr Y: 19.7 – 19.74 Mb Chr Y: 0.9 – 0.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient.

Further reading

• Simpson E, Scott D, Chandler P (1997). "The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning". Annual Review of Immunology. 15: 39–61. doi:10.1146/annurev.immunol.15.1.39. PMID 9143681.
• Wolf U (1998). "The serologically detected H-Y antigen revisited". Cytogenetics and Cell Genetics. 80 (1–4): 232–5. doi:10.1159/000014986. PMID 9678364. S2CID 25908189.
• Agulnik AI, Mitchell MJ, Lerner JL, Woods DR, Bishop CE (June 1994). "A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens". Human Molecular Genetics. 3 (6): 873–8. doi:10.1093/hmg/3.6.873. PMID 7524912.
• Wang W, Meadows LR, den Haan JM, Sherman NE, Chen Y, Blokland E, Shabanowitz J, Agulnik AI, Hendrickson RC, Bishop CE (September 1995). "Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein". Science. 269 (5230): 1588–90. Bibcode:1995Sci...269.1588W. doi:10.1126/science.7667640. hdl:1887/2988. PMID 7667640.
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Agulnik AI, Bishop CE, Lerner JL, Agulnik SI, Solovyev VV (February 1997). "Analysis of mutation rates in the SMCY/SMCX genes shows that mammalian evolution is male driven". Mammalian Genome. 8 (2): 134–8. doi:10.1007/s003359900372. PMID 9060413. S2CID 8099911.
• Rufer N, Wolpert E, Helg C, Tiercy JM, Gratwohl A, Chapuis B, Jeannet M, Goulmy E, Roosnek E (October 1998). "HA-1 and the SMCY-derived peptide FIDSYICQV (H-Y) are immunodominant minor histocompatibility antigens after bone marrow transplantation". Transplantation. 66 (7): 910–6. doi:10.1097/00007890-199810150-00016. PMID 9798702.
• Lau YF, Zhang J (April 2000). "Expression analysis of thirty one Y chromosome genes in human prostate cancer". Molecular Carcinogenesis. 27 (4): 308–21. doi:10.1002/(SICI)1098-2744(200004)27:4<308::AID-MC9>3.0.CO;2-R. PMID 10747295. S2CID 23677925.
• Shen P, Wang F, Underhill PA, Franco C, Yang WH, Roxas A, Sung R, Lin AA, Hyman RW, Vollrath D, Davis RW, Cavalli-Sforza LL, Oefner PJ (June 2000). "Population genetic implications from sequence variation in four Y chromosome genes". Proceedings of the National Academy of Sciences of the United States of America. 97 (13): 7354–9. Bibcode:2000PNAS...97.7354S. doi:10.1073/pnas.97.13.7354. PMC 16549. PMID 10861003.
• Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, Cordum HS, Hillier L, Brown LG, Repping S, Pyntikova T, Ali J, Bieri T, Chinwalla A, Delehaunty A, Delehaunty K, Du H, Fewell G, Fulton L, Fulton R, Graves T, Hou SF, Latrielle P, Leonard S, Mardis E, Maupin R, McPherson J, Miner T, Nash W, Nguyen C, Ozersky P, Pepin K, Rock S, Rohlfing T, Scott K, Schultz B, Strong C, Tin-Wollam A, Yang SP, Waterston RH, Wilson RK, Rozen S, Page DC (June 2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes". Nature. 423 (6942): 825–37. Bibcode:2003Natur.423..825S. doi:10.1038/nature01722. PMID 12815422.
• Agate RJ, Choe M, Arnold AP (February 2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches". Molecular Biology and Evolution. 21 (2): 384–96. doi:10.1093/molbev/msh027. PMID 14660691.
• Miklos DB, Kim HT, Miller KH, Guo L, Zorn E, Lee SJ, Hochberg EP, Wu CJ, Alyea EP, Cutler C, Ho V, Soiffer RJ, Antin JH, Ritz J (April 2005). "Antibody responses to H-Y minor histocompatibility antigens correlate with chronic graft-versus-host disease and disease remission". Blood. 105 (7): 2973–8. doi:10.1182/blood-2004-09-3660. PMC 1350982. PMID 15613541.
• Piper KP, McLarnon A, Arrazi J, Horlock C, Ainsworth J, Kilby MD, Martin WL, Moss PA (January 2007). "Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus". Biology of Reproduction. 76 (1): 96–101. doi:10.1095/biolreprod.106.055426. PMID 16988213.
• Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y (March 2007). "The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases". Cell. 128 (6): 1077–88. doi:10.1016/j.cell.2007.02.017. PMID 17320160. S2CID 14729302.
• Lee MG, Norman J, Shilatifard A, Shiekhattar R (March 2007). "Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein". Cell. 128 (5): 877–87. doi:10.1016/j.cell.2007.02.004. PMID 17320162. S2CID 6519228.

External links

• JARID1D+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Overview of all the structural information available in the PDB for UniProt: Q9BY66 (Lysine-specific demethylase 5D) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.