KCNIP1

K_v channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.

KCNIP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S1E, 2I2R, 2NZ0
Identifiers
Aliases	KCNIP1, KCHIP1, VABP, potassium voltage-gated channel interacting protein 1
External IDs	OMIM: 604660; MGI: 1917607; HomoloGene: 22824; GeneCards: KCNIP1; OMA:KCNIP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q35.1 Start 170,353,487 bp End 170,736,632 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 A4 Start 33,579,339 bp End 33,943,152 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nucleus accumbens anterior cingulate cortex caudate nucleus amygdala right frontal lobe prefrontal cortex hypothalamus putamen testicle dorsolateral prefrontal cortex Top expressed in habenula dorsomedial hypothalamic nucleus lateral hypothalamus ventromedial nucleus superior colliculus lobe of cerebellum cerebellar vermis paraventricular nucleus of hypothalamus lateral septal nucleus islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding potassium channel regulator activity potassium channel activity protein binding metal ion binding voltage-gated ion channel activity Cellular component cytoplasm extrinsic component of cytoplasmic side of plasma membrane voltage-gated potassium channel complex plasma membrane cell projection dendrite membrane Biological process potassium ion transport regulation of ion transmembrane transport ion transport regulation of potassium ion transmembrane transport potassium ion transmembrane transport cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 30820 70357 Ensembl ENSG00000182132 ENSMUSG00000053519 UniProt Q9NZI2 Q9JJ57 RefSeq (mRNA) NM_001034837 NM_001034838 NM_001278339 NM_001278340 NM_014592 NM_001190885 NM_001190886 NM_001290690 NM_027398 NM_001363115 RefSeq (protein) NP_001030009 NP_001030010 NP_001265268 NP_001265269 NP_055407 NP_001177814 NP_001177815 NP_001277619 NP_081674 NP_001350044 Location (UCSC) Chr 5: 170.35 – 170.74 Mb Chr 11: 33.58 – 33.94 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a member of the family of voltage-gated potassium (K_v) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native K_v4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.

See also

• Voltage-gated potassium channel

Further reading

• Bähring R, Dannenberg J, Peters HC, et al. (2001). "Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating". J. Biol. Chem. 276 (26): 23888–23894. doi:10.1074/jbc.M101320200. PMID 11287421.
• Nakamura TY, Nandi S, Pountney DJ, et al. (2001). "Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2". FEBS Lett. 499 (3): 205–209. Bibcode:2001FEBSL.499..205N. doi:10.1016/S0014-5793(01)02560-1. PMID 11423117. S2CID 23908034.
• Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome". Nucleic Acids Res. 30 (14): 3163–3170. doi:10.1093/nar/gkf428. PMC 135748. PMID 12136098.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shibata R, Misonou H, Campomanes CR, et al. (2003). "A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels". J. Biol. Chem. 278 (38): 36445–36454. doi:10.1074/jbc.M306142200. PMID 12829703.
• Van Hoorick D, Raes A, Keysers W, et al. (2004). "Differential modulation of Kv4 kinetics by KCHIP1 splice variants". Mol. Cell. Neurosci. 24 (2): 357–366. doi:10.1016/S1044-7431(03)00174-X. PMID 14572458. S2CID 40647616.
• Scannevin RH, Wang K, Jow F, et al. (2004). "Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1". Neuron. 41 (4): 587–598. doi:10.1016/S0896-6273(04)00049-2. PMID 14980207. S2CID 17380435.
• Lin YL, Lin SR, Wu TT, Chang LS (2004). "Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins". Biochem. Biophys. Res. Commun. 319 (3): 720–724. doi:10.1016/j.bbrc.2004.05.064. PMID 15184042.
• Lin YL, Chen CY, Cheng CP, Chang LS (2004). "Protein-protein interactions of KChIP proteins and Kv4.2". Biochem. Biophys. Res. Commun. 321 (3): 606–610. doi:10.1016/j.bbrc.2004.07.006. PMID 15358149.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pruunsild P, Timmusk T (2005). "Structure, alternative splicing, and expression of the human and mouse KCNIP gene family". Genomics. 86 (5): 581–593. doi:10.1016/j.ygeno.2005.07.001. PMID 16112838.
• Pioletti M, Findeisen F, Hura GL, Minor DL (2007). "Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer". Nat. Struct. Mol. Biol. 13 (11): 987–995. doi:10.1038/nsmb1164. PMC 3018330. PMID 17057713.{{cite journal}}: CS1 maint: multiple names: authors list (link)
• Hasdemir B, Fitzgerald DJ, Prior IA, Tepikin AV, Burgoyne RD (2005). "Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway". J. Cell Biol. 171 (3): 459–469. doi:10.1083/jcb.200506005. PMC 2171252. PMID 16260497.
• Venn N, Haynes LP, Burgoyne RD (2008). "Specific effects of KChIP3/calsenilin/DREAM but not KChIPs1, 2 and 4 on calcium signalling and regulated secretion in PC12 cells". Biochem. J. 413 (1): 71–80. doi:10.1042/BJ20080441. PMC 2474559. PMID 18393943.

External links

• KCNIP1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.