Jayasekara is a Sinhalese name that may refer to the following people:
- Surname
- Dayasiri Jayasekara (born 1969), Sri Lankan politician
- P.B Jayasekara, Sri Lankan writer and translator
- Premalal Jayasekara (born 1974), Sri Lankan politician and convicted murderer
- Forename
- Jayasekara Aponsu (born 1951), Sri Lankan actor