Jaffee is the surname of:

  • Al Jaffee (1921–2023), American cartoonist best known for his work for Mad magazine
  • Elizabeth Jaffee, American medical researcher
  • Ellen Jaffee (born 1944), member of the New York State Assembly
  • Irving Jaffee (1906–1981), American speed skater and double gold medalist at the 1932 Winter Olympics
  • Rami Jaffee (born 1969), American keyboardist of the rock band The Wallflowers
  • Sara Jaffee, American psychologist
  • Susan Nirah Jaffee, American screenwriter and television producer

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