JUB (gene)

Protein ajuba is a protein that in humans is encoded by the JUB gene.

AJUBA
Identifiers
Aliases	AJUBA, JUB, ajuba LIM protein
External IDs	OMIM: 609066; MGI: 1341886; HomoloGene: 7789; GeneCards: AJUBA; OMA:AJUBA - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 22,971,177 bp End 22,982,551 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 C2 Start 54,804,929 bp End 54,815,015 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium skin of arm ventricular zone gingival epithelium skin of thigh skin of abdomen amniotic fluid skin of hip stromal cell of endometrium visceral pleura Top expressed in molar somite endocardial cushion renal corpuscle epiblast primitive streak external carotid artery epithelium of lens abdominal wall Gonadal ridge More reference expression data BioGPS n/a
Gene ontology Molecular function transcription corepressor activity chromatin binding metal ion binding actin filament binding protein binding alpha-catenin binding Cellular component cytoplasm membrane focal adhesion cell-cell junction plasma membrane P-body microtubule organizing center cell junction cytoskeleton nucleus lamellipodium transcription regulator complex Golgi apparatus cytosol adherens junction Biological process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules regulation of cell migration response to hypoxia positive regulation of MAP kinase activity positive regulation of protein-containing complex assembly regulation of GTPase activity wound healing, spreading of epidermal cells positive regulation of kinase activity positive regulation of cellular biosynthetic process negative regulation of transcription by RNA polymerase II transcription, DNA-templated positive regulation of gene silencing by miRNA regulation of cellular response to hypoxia glycerophospholipid biosynthetic process focal adhesion assembly cell adhesion G2/M transition of mitotic cell cycle gene silencing by miRNA negative regulation of hippo signaling positive regulation of I-kappaB kinase/NF-kappaB signaling cell cycle gene silencing lamellipodium assembly negative regulation of kinase activity regulation of transcription, DNA-templated cytoskeleton organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84962 16475 Ensembl ENSG00000129474 ENSMUSG00000022178 UniProt Q96IF1 Q91XC0 RefSeq (mRNA) NM_198086 NM_001289097 NM_032876 NM_010590 RefSeq (protein) NP_001276026 NP_116265 NP_932352 NP_034720 Location (UCSC) Chr 14: 22.97 – 22.98 Mb Chr 14: 54.8 – 54.82 Mb PubMed search
Wikidata
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Function

JUB proteins contribute to cell fate determination and regulate cell proliferation and differentiation. Plays an important role in regulation of the kinase activity of AURKA/Aurora-A for mitotic commitment.

Interactions

JUB (gene) has been shown to interact with Stratifin and SLC1A2.

Further reading

• Kanungo J, Pratt SJ, Marie H, Longmore GD (2000). "Ajuba, a Cytosolic LIM Protein, Shuttles into the Nucleus and Affects Embryonal Cell Proliferation and Fate Decisions". Mol. Biol. Cell. 11 (10): 3299–313. doi:10.1091/mbc.11.10.3299. PMC 14993. PMID 11029037.
• Marie H, Billups D, Bedford FK, Dumoulin A, Goyal RK, Longmore GD, Moss SJ, Attwell D (2002). "The amino terminus of the glial glutamate transporter GLT-1 interacts with the LIM protein Ajuba". Mol. Cell. Neurosci. 19 (2): 152–64. doi:10.1006/mcne.2001.1066. PMID 11860269. S2CID 45768895.
• Marie H, Pratt SJ, Betson M, Epple H, Kittler JT, Meek L, Moss SJ, Troyanovsky S, Attwell D, Longmore GD, Braga VM (2003). "The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin". J. Biol. Chem. 278 (2): 1220–8. doi:10.1074/jbc.M205391200. PMID 12417594.
• Hirota T, Kunitoku N, Sasayama T, Marumoto T, Zhang D, Nitta M, Hatakeyama K, Saya H (2003). "Aurora-A and an interacting activator, the LIM protein Ajuba, are required for mitotic commitment in human cells". Cell. 114 (5): 585–98. doi:10.1016/S0092-8674(03)00642-1. PMID 13678582.
• Pratt SJ, Epple H, Ward M, Feng Y, Braga VM, Longmore GD (2005). "The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration". J. Cell Biol. 168 (5): 813–24. doi:10.1083/jcb.200406083. PMC 2171823. PMID 15728191.
• Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
• Kisseleva M, Feng Y, Ward M, Song C, Anderson RA, Longmore GD (2005). "The LIM Protein Ajuba Regulates Phosphatidylinositol 4,5-Bisphosphate Levels in Migrating Cells through an Interaction with and Activation of PIPKIα". Mol. Cell. Biol. 25 (10): 3956–66. doi:10.1128/MCB.25.10.3956-3966.2005. PMC 1087706. PMID 15870270.
• Feng Y, Longmore GD (2005). "The LIM Protein Ajuba Influences Interleukin-1-Induced NF-κB Activation by Affecting the Assembly and Activity of the Protein Kinase Cζ/p62/TRAF6 Signaling Complex". Mol. Cell. Biol. 25 (10): 4010–22. doi:10.1128/MCB.25.10.4010-4022.2005. PMC 1087715. PMID 15870274.
• Abe Y, Ohsugi M, Haraguchi K, Fujimoto J, Yamamoto T (2006). "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis". FEBS Lett. 580 (3): 782–8. doi:10.1016/j.febslet.2005.12.096. PMID 16413547.
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Alagaratnam S, Hardy JR, Lothe RA, Skotheim RI, Byrne JA (2008). "TPD52, a candidate gene from genomic studies, is overexpressed in testicular germ cell tumours". Mol. Cell. Endocrinol. 306 (1–2): 75–80. doi:10.1016/j.mce.2008.10.043. PMID 19041365. S2CID 5456314.