Interleukin-21 receptor

Interleukin 21 receptor is a type I cytokine receptor. IL21R is its human gene.[5]

IL21R
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesIL21R, CD360, NILR, interleukin 21 receptor, IMD56
External IDsOMIM: 605383; MGI: 1890475; HomoloGene: 11040; GeneCards: IL21R; OMA:IL21R - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021798
NM_181078
NM_181079

NM_021887

RefSeq (protein)

NP_068570
NP_851564
NP_851565

NP_068687

Location (UCSC)Chr 16: 27.4 – 27.45 MbChr 7: 125.2 – 125.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma chain (γc), a receptor subunit also shared by the receptors for interleukin 2 (IL2), interleukin 7 (IL7) and interleukin 15 (IL15). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000103522Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030745Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: IL21R interleukin 21 receptor".

Further reading

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