Integrator complex subunit 5

INTS5
Identifiers
Aliases	INTS5, INT5, KIAA1698, integrator complex subunit 5
External IDs	OMIM: 611349; MGI: 1923578; HomoloGene: 35303; GeneCards: INTS5; OMA:INTS5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,653,302 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,875,252 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; granulocyte; ; gastrocnemius muscle; ; mucosa of transverse colon; ; islet of Langerhans; ; apex of heart; ; right adrenal gland; ; skin of leg; ; right lobe of liver; ; muscle of thigh;
	Top expressed in
	epiblast; ; corneal stroma; ; renal corpuscle; ; primitive streak; ; ventricular zone; ; maxillary prominence; ; internal carotid artery; ; mandibular prominence; ; neural tube; ; yolk sac;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	integrator complex; integral component of membrane; membrane; nucleus; nucleoplasm; nuclear membrane; cytoplasm;
Biological process	snRNA processing; snRNA transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	80789
	109077
	ENSG00000185085
	ENSMUSG00000071652
	Q6P9B9
	Q8CHT3
	NM_030628
	NM_176843
	NP_085131
	NP_789813
	Wikidata
View/Edit Human	View/Edit Mouse

Integrator complex subunit 5 is a protein that in humans is encoded by the INTS5 gene. ^[5]

Function

The Integrator complex is a complex that associates with the C-terminal domain of RNA polymerase II large subunit. This complex is brought to U1 and U2 small nuclear RNA genes, where it is involved in the transcription and processing of their transcripts. The protein encoded by this gene represents a subunit of the Integrator complex.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185085 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000071652 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Integrator complex subunit 5". Retrieved 2017-10-09.

Integrator complex subunit 5

Function

References

Further reading