Indium (111In) biciromab (INN, trade name FibriScint, developed by Centocor) was a drug targeting fibrin, a protein involved in the clotting of blood.[1] It was the Fab' fragment of a mouse monoclonal antibody labelled with the radioisotope indium-111 for the diagnosis of thromboembolism,[2] but was withdrawn during clinical trials.[3]
| Monoclonal antibody | |
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| Type | Fab' fragment |
| Source | Mouse |
| Target | Fibrin II, beta chain |
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| Trade names | FibriScint |
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References
edit- ^ King DJ, Adair JR (March 1999). "Recombinant antibodies for the diagnosis and therapy of human diseases". Current Opinion in Drug Discovery & Development. 2 (2): 110–7. PMID 19649936.
- ^ "Centocor Ortho Biotech Products, L.P." Answers.com.
- ^ "Centocor withdraws imaging agent applications". DiagnosticImaging.com.
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