The ISO61 (IsrA) RNA is a bacterial non-coding RNA that is found between the abgR and ydaL genes in Escherichia coli and Shigella flexneri. It was discovered using a computational screen of the E. coli genome.[1] Subsequent characterisation of ISO61 region has revealed that the reverse strand is actually a CsrA binding ncRNA called McaS and that it has a role in biofilm formation control.[2] Furthermore, it has been shown that McaS(IsrA) exists as ribonucleoprotein particles (sRNPs), which involve a defined set of proteins including Hfq, S1, CsrA, ProQ and PNPase. [3]
| IS061 RNA | |
|---|---|
 Predicted secondary structure and sequence conservation of IS061 | |
| Identifiers | |
| Symbol | IS061 |
| Rfam | RF00115 |
| Other data | |
| RNA type | Gene; sRNA |
| Domain(s) | Bacteria |
| SO | SO:0001263 |
| PDB structures | PDBe |
See also
editReferences
edit- ^ Chen S, Lesnik EA, Hall TA, Sampath R, Griffey RH, Ecker DJ, Blyn LB (2002). "A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome". Bio Systems. 65 (2–3): 157–177. doi:10.1016/S0303-2647(02)00013-8. PMID 12069726.
- ^ Jørgensen MG, Thomason MK, Havelund J, Valentin-Hansen P, Storz G (May 2013). "Dual function of the McaS small RNA in controlling biofilm formation". Genes & Development. 27 (10): 1132–1145. doi:10.1101/gad.214734.113. PMC 3672647. PMID 23666921.
- ^ van Nues RW, Castro-Roa D, Yuzenkova Y, Zenkin N (April 2016). "Ribonucleoprotein particles of bacterial small non-coding RNA IsrA (IS61 or McaS) and its interaction with RNA polymerase core may link transcription to mRNA fate". Nucleic Acids Research. 44 (6): 2577–2592. doi:10.1093/nar/gkv1302. PMC 4824073. PMID 26609136.
External links
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