INPP5F

Inositol polyphosphate-5-phosphatase F is a protein that in humans is encoded by the INPP5F gene.

INPP5F
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XUU
Identifiers
Aliases	INPP5F, MSTPO47, SAC2, hSAC2, MSTP007, inositol polyphosphate-5-phosphatase F
External IDs	OMIM: 609389; MGI: 2141867; HomoloGene: 8962; GeneCards: INPP5F; OMA:INPP5F - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q26.11 Start 119,726,042 bp End 119,829,147 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F3 Start 128,611,328 bp End 128,696,425 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Pons superior vestibular nucleus lateral nuclear group of thalamus Brodmann area 23 orbitofrontal cortex pars compacta middle temporal gyrus ventral tegmental area secondary oocyte Region I of hippocampus proper Top expressed in nucleus accumbens pontine nuclei lateral hypothalamus dorsal tegmental nucleus ventral tegmental area globus pallidus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus suprachiasmatic nucleus Region I of hippocampus proper More reference expression data BioGPS n/a
Gene ontology Molecular function inositol monophosphate 1-phosphatase activity inositol monophosphate phosphatase activity protein homodimerization activity inositol monophosphate 3-phosphatase activity protein binding phosphoric ester hydrolase activity hydrolase activity inositol monophosphate 4-phosphatase activity phosphatidylinositol phosphate 4-phosphatase activity phosphatidylinositol phosphate 5-phosphatase activity phosphatidylinositol-4-phosphate phosphatase activity Cellular component dendrite clathrin-coated pit membrane clathrin-coated endocytic vesicle cytoplasm early endosome membrane endosome recycling endosome early endosome axon soma Biological process phosphatidylinositol catabolic process cardiac muscle hypertrophy in response to stress regulation of protein kinase B signaling phosphatidylinositol-mediated signaling clathrin-dependent endocytosis positive regulation of receptor recycling phosphatidylinositol dephosphorylation negative regulation of axon regeneration phosphatidylinositol biosynthetic process adult locomotory behavior regulation of endocytic recycling regulation of cell motility negative regulation of peptidyl-serine phosphorylation negative regulation of tyrosine phosphorylation of STAT protein Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22876 101490 Ensembl ENSG00000198825 ENSMUSG00000042105 UniProt Q9Y2H2 Q8CDA1 RefSeq (mRNA) NM_001243194 NM_001243195 NM_014937 NM_178641 NM_001346517 RefSeq (protein) NP_001230123 NP_001230124 NP_055752 NP_001333446 NP_848756 Location (UCSC) Chr 10: 119.73 – 119.83 Mb Chr 7: 128.61 – 128.7 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase and contains a Sac domain. The activity of this protein is specific for phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].

Further reading

• Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A (January 2006). "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease". Am. J. Hum. Genet. 78 (1): 78–88. doi:10.1086/498851. PMC 1380225. PMID 16385451.
• Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA (December 2009). "Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness". Circ. Res. 105 (12): 1240–7. doi:10.1161/CIRCRESAHA.109.208785. PMC 2802340. PMID 19875726.
• Kim HS, Li A, Ahn S, Song H, Zhang W (December 2014). "Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity". Sci Rep. 4: 7330. Bibcode:2014NatSR...4E7330K. doi:10.1038/srep07330. PMC 4256660. PMID 25476455.
• Hsu F, Hu F, Mao Y (April 2015). "Spatiotemporal control of phosphatidylinositol 4-phosphate by Sac2 regulates endocytic recycling". J. Cell Biol. 209 (1): 97–110. doi:10.1083/jcb.201408027. PMC 4395482. PMID 25869669.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.