INHBC

Inhibin beta C chain is a protein that in humans is encoded by the INHBC gene.

INHBC
Identifiers
Aliases	INHBC, IHBC, inhibin beta C, inhibin beta C subunit, inhibin subunit beta C
External IDs	OMIM: 601233; MGI: 105932; HomoloGene: 21142; GeneCards: INHBC; OMA:INHBC - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.3 Start 57,434,784 bp End 57,452,062 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 D3|10 74.5 cM Start 127,192,191 bp End 127,206,300 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle tibialis anterior muscle pancreatic ductal cell mucosa of ileum deltoid muscle skin of thigh cerebellum cerebellar cortex right hemisphere of cerebellum Top expressed in liver yolk sac embryo embryo placenta islet of Langerhans More reference expression data BioGPS More reference expression data
Gene ontology Molecular function growth factor activity transforming growth factor beta receptor binding hormone activity cytokine activity Cellular component extracellular region extracellular space Biological process positive regulation of pathway-restricted SMAD protein phosphorylation regulation of MAPK cascade cell development regulation of apoptotic process SMAD protein signal transduction regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3626 16325 Ensembl ENSG00000175189 ENSMUSG00000025405 UniProt P55103 P55104 RefSeq (mRNA) NM_005538 NM_010565 RefSeq (protein) NP_005529 NP_034695 Location (UCSC) Chr 12: 57.43 – 57.45 Mb Chr 10: 127.19 – 127.21 Mb PubMed search
Wikidata
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This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.

Further reading

• Bernard DJ, Chapman SC, Woodruff TK (2001). "Mechanisms of inhibin signal transduction". Recent Prog. Horm. Res. 56: 417–50. doi:10.1210/rp.56.1.417. PMID 11237224.
• Mathews LS, Vale WW (1991). "Expression cloning of an activin receptor, a predicted transmembrane serine kinase". Cell. 65 (6): 973–82. doi:10.1016/0092-8674(91)90549-E. PMID 1646080. S2CID 36407277.
• Schmitt J, Hötten G, Jenkins NA, et al. (1997). "Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin beta C (Inhbc) gene". Genomics. 32 (3): 358–66. doi:10.1006/geno.1996.0130. PMID 8838799.
• Thomas TZ, Chapman SM, Hong W, et al. (1998). "Inhibins, activins, and follistatins: expression of mRNAs and cellular localization in tissues from men with benign prostatic hyperplasia". Prostate. 34 (1): 34–43. doi:10.1002/(SICI)1097-0045(19980101)34:1<34::AID-PROS5>3.0.CO;2-K. PMID 9428386. S2CID 45515214.
• Mellor SL, Cranfield M, Ries R, et al. (2001). "Localization of activin beta(A)-, beta(B)-, and beta(C)-subunits in humanprostate and evidence for formation of new activin heterodimers of beta(C)-subunit". J. Clin. Endocrinol. Metab. 85 (12): 4851–8. doi:10.1210/jcem.85.12.7052. PMID 11134153.
• Casagrandi D, Bearfield C, Geary J, et al. (2003). "Inhibin, activin, follistatin, activin receptors and beta-glycan gene expression in the placental tissue of patients with pre-eclampsia". Mol. Hum. Reprod. 9 (4): 199–203. doi:10.1093/molehr/gag029. PMID 12651901.
• Mellor SL, Ball EM, O'Connor AE, et al. (2003). "Activin betaC-subunit heterodimers provide a new mechanism of regulating activin levels in the prostate". Endocrinology. 144 (10): 4410–9. doi:10.1210/en.2003-0225. PMID 12960042.
• Ushiro Y, Hashimoto O, Seki M, et al. (2007). "Analysis of the function of activin betaC subunit using recombinant protein". J. Reprod. Dev. 52 (4): 487–95. doi:10.1262/jrd.17110. PMID 16627954.