Halperin (sometimes spelled as Halparin or Hailperin) is a variation of the Jewish surname Heilprin. Both forms are Southern Yiddish for Heilbrun, that is the German city Heilbronn. The name is sometimes transliterated into the Cyrillic alphabet as Galperin (the Russian letter Ge used to be pronounced closer to German H in many words).

The German form of the Jewish surname is Heilbronn.

Notable people with this surname include:

Elchonon Halpern, (1921- 2015), Grand Rabbi of Golders Green. In Hebrew spelt היילפרין, literally pronounced 'Heilprin'

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