HP1BP3

HP1BP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RQP
Identifiers
Aliases	HP1BP3, HP1-BP74, HP1BP74, heterochromatin protein 1 binding protein 3
External IDs	OMIM: 616072; MGI: 109369; HomoloGene: 7774; GeneCards: HP1BP3; OMA:HP1BP3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	20,787,323 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	137,971,994 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; ventricular zone; ; tibia; ; trabecular bone; ; parietal pleura; ; visceral pleura; ; skin of hip; ; Achilles tendon; ; parotid gland; ; seminal vesicula;
	Top expressed in
	renal corpuscle; ; medullary collecting duct; ; ventricular zone; ; condyle; ; ascending aorta; ; aortic valve; ; neural layer of retina; ; ganglionic eminence; ; vestibular membrane of cochlear duct; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleosome binding; protein binding; chromatin binding;
Cellular component	nucleosome; nucleus; chromosome; nuclear speck;
Biological process	regulation of nucleus size; nucleosome assembly; heterochromatin organization; regulation of transcription, DNA-templated; regulation of cell population proliferation; cellular response to hypoxia;
	Sources:Amigo / QuickGO
Orthologs
	50809
	15441
	ENSG00000127483
	ENSMUSG00000028759
	Q5SSJ5
	Q3TEA8
	NM_016287; NM_001372052
NM_001122896; NM_001122897; NM_001285478; NM_001285479; NM_001285480;
	NM_001285481; NM_010470; NM_001356431; NM_001356432
NP_057371; NP_001358981; NP_001363716; NP_001363717; NP_001363718;
	NP_001363719; NP_001363720; NP_001363721; NP_001363722; NP_001363723; NP_001363724; NP_001363725; NP_001363726
NP_001116368; NP_001116369; NP_001272407; NP_001272408; NP_001272409;
	NP_001272410; NP_034600; NP_001343360; NP_001343361
	Wikidata
View/Edit Human	View/Edit Mouse

Heterochromatin protein 1, binding protein 3 is a protein that in humans is encoded by the HP1BP3 gene.^[5] It has been identified as a novel subtype of the linker histone H1, involved in the structure of heterochromatin ^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127483 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028759 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: heterochromatin protein 1, binding protein 3". Retrieved 2011-08-30.
^ Garfinkel BP, Melamed-Book N, Anuka E, Bustin M, Orly J (February 2015). "HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth". Nucleic Acids Research. 43 (4): 2074–90. doi:10.1093/nar/gkv089. PMC 4344522. PMID 25662603.
^ Dutta B, Ren Y, Hao P, Sim KH, Cheow E, Adav S, Tam JP, Sze SK (September 2014). "Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression". Molecular & Cellular Proteomics. 13 (9): 2183–97. doi:10.1074/mcp.M113.034975. PMC 4159643. PMID 24830416.
^ Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi:10.1074/jbc.M109.092833. PMC 2825445. PMID 20042602.

Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Ouyang J, Shi Y, Valin A, Xuan Y, Gill G (April 2009). "Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex". Molecular Cell. 34 (2): 145–54. doi:10.1016/j.molcel.2009.03.013. PMC 2727917. PMID 19394292.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW (April 2009). "Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia". European Archives of Psychiatry and Clinical Neuroscience. 259 (3): 151–63. doi:10.1007/s00406-008-0847-2. PMID 19165527. S2CID 33815571.
Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (December 2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutation Research. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.
Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi:10.1074/jbc.M109.092833. PMC 2825445. PMID 20042602.
Gautier VW, Gu L, O'Donoghue N, Pennington S, Sheehy N, Hall WW (2009). "In vitro nuclear interactome of the HIV-1 Tat protein". Retrovirology. 6: 47. doi:10.1186/1742-4690-6-47. PMC 2702331. PMID 19454010.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000127483 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028759 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: heterochromatin protein 1, binding protein 3". Retrieved 2011-08-30.

[6] Garfinkel BP, Melamed-Book N, Anuka E, Bustin M, Orly J (February 2015). "HP1BP3 is a novel histone H1 related protein with essential roles in viability and growth". Nucleic Acids Research. 43 (4): 2074–90. doi:10.1093/nar/gkv089. PMC 4344522. PMID 25662603.

[7] Dutta B, Ren Y, Hao P, Sim KH, Cheow E, Adav S, Tam JP, Sze SK (September 2014). "Profiling of the Chromatin-associated Proteome Identifies HP1BP3 as a Novel Regulator of Cell Cycle Progression". Molecular & Cellular Proteomics. 13 (9): 2183–97. doi:10.1074/mcp.M113.034975. PMC 4159643. PMID 24830416.

[8] Hayashihara K, Uchiyama S, Shimamoto S, Kobayashi S, Tomschik M, Wakamatsu H, No D, Sugahara H, Hori N, Noda M, Ohkubo T, Zlatanova J, Matsunaga S, Fukui K (February 2010). "The middle region of an HP1-binding protein, HP1-BP74, associates with linker DNA at the entry/exit site of nucleosomal DNA". The Journal of Biological Chemistry. 285 (9): 6498–507. doi:10.1074/jbc.M109.092833. PMC 2825445. PMID 20042602.

[5]

[6]

[7]

[8]

[1]

[2]

[3]

[4]

HP1BP3

References

Further reading