HOXB4

Homeobox protein Hox-B4 is a protein that in humans is encoded by the HOXB4 gene.

HOXB4
Identifiers
Aliases	HOXB4, HOX-2.6, HOX2, HOX2F, homeobox B4
External IDs	OMIM: 142965; MGI: 96185; HomoloGene: 32095; GeneCards: HOXB4; OMA:HOXB4 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q21.32 Start 48,575,507 bp End 48,578,350 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 D|11 59.83 cM Start 96,209,093 bp End 96,212,464 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube muscle layer of sigmoid colon gastric mucosa endometrium Descending thoracic aorta left uterine tube human kidney right lung fundus right adrenal gland Top expressed in tail of embryo thoracic vertebral column migratory enteric neural crest cell medullary collecting duct ascending aorta granulocyte female urethra inner root sheath primitive streak renal corpuscle More reference expression data BioGPS n/a
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component nucleus centrosome Biological process embryonic skeletal system morphogenesis multicellular organism development definitive hemopoiesis somatic stem cell division skeletal system morphogenesis cell population proliferation positive regulation of stem cell differentiation regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II spleen development hematopoietic stem cell differentiation morphogenesis of an epithelial sheet transcription, DNA-templated anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II bone marrow development hemopoiesis skeletal system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3214 15412 Ensembl ENSG00000182742 ENSMUSG00000038692 UniProt P17483 P10284 RefSeq (mRNA) NM_024015 NM_010459 RefSeq (protein) NP_076920 NP_034589 Location (UCSC) Chr 17: 48.58 – 48.58 Mb Chr 11: 96.21 – 96.21 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

See also

• Homeobox

Further reading

• Petrini M, Quaranta MT, Testa U, Samoggia P, Tritarelli E, Carè A, Cianetti L, Valtieri M, Barletta C, Peschle C (Jul 1992). "Expression of selected human HOX-2 genes in B/T acute lymphoid leukemia and interleukin-2/interleukin-1 beta-stimulated natural killer lymphocytes". Blood. 80 (1): 185–93. doi:10.1182/blood.V80.1.185.185. PMID 1351762.
• Peverali FA, D'Esposito M, Acampora D, Bunone G, Negri M, Faiella A, Stornaiuolo A, Pannese M, Migliaccio E, Simeone A (Oct 1990). "Expression of HOX homeogenes in human neuroblastoma cell culture lines". Differentiation; Research in Biological Diversity. 45 (1): 61–9. doi:10.1111/j.1432-0436.1990.tb00458.x. PMID 1981366.
• Giampaolo A, Acampora D, Zappavigna V, Pannese M, D'Esposito M, Carè A, Faiella A, Stornaiuolo A, Russo G, Simeone A (Jun 1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation; Research in Biological Diversity. 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
• Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989). "The human HOX gene family". Nucleic Acids Research. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMC 335308. PMID 2574852.
• Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes". Genome. 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
• Kuliev A, Kukharenko V, Morozov G, Freidine M, Rechitsky S, Verlinsky O, Ivakhnenko V, Gindilis V, Strom C, Verlinsky Y (Feb 1996). "Expression of homebox-containing genes in human preimplantation development and in embryos with chromosomal aneuploidies". Journal of Assisted Reproduction and Genetics. 13 (2): 177–81. doi:10.1007/BF02072541. PMID 8688592. S2CID 28126784.
• Bonaldo MF, Lennon G, Soares MB (Sep 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Bodey B, Bodey B, Siegel SE, Kaiser HE (2000). "Immunocytochemical detection of the homeobox B3, B4, and C6 gene products within the human thymic cellular microenvironment". In Vivo. 14 (3): 419–24. PMID 10904875.
• Giannola DM, Shlomchik WD, Jegathesan M, Liebowitz D, Abrams CS, Kadesch T, Dancis A, Emerson SG (Nov 2000). "Hematopoietic expression of HOXB4 is regulated in normal and leukemic stem cells through transcriptional activation of the HOXB4 promoter by upstream stimulating factor (USF)-1 and USF-2". The Journal of Experimental Medicine. 192 (10): 1479–90. doi:10.1084/jem.192.10.1479. PMC 2193192. PMID 11085749.
• Pan Q, Simpson RU (Apr 2001). "Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression". The Journal of Endocrinology. 169 (1): 153–9. doi:10.1677/joe.0.1690153. PMID 11250656.
• Shen WF, Krishnan K, Lawrence HJ, Largman C (Nov 2001). "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology. 21 (21): 7509–22. doi:10.1128/MCB.21.21.7509-7522.2001. PMC 99922. PMID 11585930.
• Kömüves LG, Michael E, Arbeit JM, Ma XK, Kwong A, Stelnicki E, Rozenfeld S, Morimune M, Yu QC, Largman C (May 2002). "HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation". Developmental Dynamics. 224 (1): 58–68. doi:10.1002/dvdy.10085. PMID 11984874. S2CID 19816254.
• Buske C, Feuring-Buske M, Abramovich C, Spiekermann K, Eaves CJ, Coulombel L, Sauvageau G, Hogge DE, Humphries RK (Aug 2002). "Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells". Blood. 100 (3): 862–8. doi:10.1182/blood-2002-01-0220. PMID 12130496.
• Schiedlmeier B, Klump H, Will E, Arman-Kalcek G, Li Z, Wang Z, Rimek A, Friel J, Baum C, Ostertag W (Mar 2003). "High-level ectopic HOXB4 expression confers a profound in vivo competitive growth advantage on human cord blood CD34+ cells, but impairs lymphomyeloid differentiation". Blood. 101 (5): 1759–68. doi:10.1182/blood-2002-03-0767. PMID 12406897.
• Theokli C, Morsi El-Kadi AS, Morgan R (May 2003). "TALE class homeodomain gene Irx5 is an immediate downstream target for Hoxb4 transcriptional regulation". Developmental Dynamics. 227 (1): 48–55. doi:10.1002/dvdy.10287. PMID 12701098. S2CID 10293029.
• Kömüves LG, Ma XK, Stelnicki E, Rozenfeld S, Oda Y, Largman C (Jun 2003). "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development". Developmental Dynamics. 227 (2): 192–202. doi:10.1002/dvdy.10290. PMID 12761847. S2CID 42243036.
• Zhu J, Giannola DM, Zhang Y, Rivera AJ, Emerson SG (Oct 2003). "NF-Y cooperates with USF1/2 to induce the hematopoietic expression of HOXB4". Blood. 102 (7): 2420–7. doi:10.1182/blood-2003-01-0251. PMID 12791656.

External links

• HOXB4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.