Histone H2B type 3-B is a protein that in humans is encoded by the HIST3H2BB gene.[5][6]

H2BU1
Identifiers
AliasesH2BU1, H2Bb, histone cluster 3, H2bb, histone cluster 3 H2B family member b, H2B.U histone 1, HIST3H2BB
External IDsOMIM: 615046; MGI: 1922442; HomoloGene: 75941; GeneCards: H2BU1; OMA:H2BU1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_175055

NM_001393523

RefSeq (protein)

NP_778225

n/a

Location (UCSC)Chr 1: 228.46 – 228.46 MbChr 11: 58.84 – 58.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 base pairs (bp) of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.[6]

References

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  1. ^ a b c ENSG00000285449 GRCh38: Ensembl release 89: ENSG00000196890, ENSG00000285449Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000080712Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  6. ^ a b "Entrez Gene: HIST3H2BB histone cluster 3, H2bb".

Further reading

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