HIST1H4I

Histone H4 is a protein that, in humans, is encoded by the HIST1H4I gene.

H4C9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4H9O, 3WKJ, 3AYW, 3WA9, 5B0Z, 5AVB, 2CV5, 5AV5, 3AV2, 3WTP, 3AV1, 3AZK, 3X1V, 5AV8, 1F66, 4QUU, 3CFS, 4YYK, 4QUT, 3NQJ, 3A6N, 3W99, 5AVC, 2RS9, 3F9Z, 3QZT, 3QBY, 3W97, 4M38, 4YM6, 3CFV, 4HGA, 1EQZ, 2RJE, 3QZV, 1HQ3, 4H9P, 3AZL, 3AFA, 1TZY, 3UVY, 5CPK, 3JPX, 4U9W, 4N3W, 4YYJ, 4YYD, 4H9N, 4H9R, 3AZI, 4LD9, 3UVX, 3AZH, 5BNX, 4N4F, 1U35, 4YYG, 3O36, 2ARO, 5AV9, 4H9S, 3AZF, 3W98, 4GQB, 4H9Q, 5BNV, 3WAA, 3AZG, 3AZE, 2RNY, 1ZKK, 2QQS, 2LVM, 3X1T, 3AN2, 2KWO, 3QZS, 3F9W, 5FFW, 5CPJ, 3F9X, 3IJ1, 4YM5, 3AZJ, 4YY6, 3AZN, 2IG0, 4YYH, 4YYI, 5CPI, 3W96, 3R45, 2KWN, 3F9Y, 5AV6, 3AZM, 5BO0, 3X1S, 4QYD, 4KGC, 3UVW, 4YYN, 3X1U, 3UW9, 2F8N, 3NQU, 5B0Y, 4YYM, 5C3I, 4Z5T, 5B24, 5FA5, 4Z2M, 5E5A, 5FWE, 5B2I, 5B40, 5B2J, 5JA4, 5AY8, 4ZUX
Identifiers
Aliases	H4C9, H4/m, H4FM, H4M, histone cluster 1, H4i, histone cluster 1 H4 family member i, H4 clustered histone 9, HIST1H4I, H4C5, H4C4, H4C12, H4-16, H4C3, H4C13, H4C11, H4C1, H4C14, H4C15, H4C8, H4C6, H4C2
External IDs	OMIM: 602833; MGI: 2448427; HomoloGene: 134482; GeneCards: H4C9; OMA:H4C9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.1 Start 27,139,282 bp End 27,139,678 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.1 Start 23,715,220 bp End 23,715,689 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad bone marrow cells monocyte mucosa of transverse colon blood right lobe of liver spleen body of pancreas mucosa of esophagus Top expressed in soleus muscle spermatocyte muscle of thigh intercostal muscle right kidney myocardium of ventricle thoracic diaphragm yolk sac extraocular muscle gastrocnemius muscle More reference expression data BioGPS n/a
Gene ontology Molecular function protein domain specific binding protein binding protein heterodimerization activity DNA binding histone binding RNA binding Cellular component membrane chromosome nucleoplasm extracellular region nuclear chromosome nucleosome extracellular exosome nucleus extracellular matrix protein-containing complex Biological process telomere organization epigenetic maintenance of chromatin in transcription-competent conformation protein heterotetramerization negative regulation of megakaryocyte differentiation CENP-A containing chromatin assembly DNA replication-dependent chromatin assembly rDNA heterochromatin assembly negative regulation of gene expression, epigenetic DNA-templated transcription, initiation double-strand break repair via nonhomologous end joining beta-catenin-TCF complex assembly telomere capping nucleosome assembly regulation of gene silencing by miRNA regulation of megakaryocyte differentiation regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8294 69386 Ensembl ENSG00000276180 ENSMUSG00000060981 UniProt P62805 P62806 RefSeq (mRNA) NM_003495 NM_153173 RefSeq (protein) NP_003537 NP_003486 NP_003535 NP_003539 NP_003531 NP_003536 NP_291074 NP_783587 NP_783588 NP_835499 NP_835500 NP_001182350 NP_835515 NP_783585 NP_783586 NP_835582 NP_835583 NP_783583 NP_694813 Location (UCSC) Chr 6: 27.14 – 27.14 Mb Chr 13: 23.72 – 23.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.

Further reading

• Albig W, Kardalinou E, Drabent B, Zimmer A, Doenecke D (1991). "Isolation and characterization of two human H1 histone genes within clusters of core histone genes". Genomics. 10 (4): 940–8. doi:10.1016/0888-7543(91)90183-F. PMID 1916825.
• Turner BM, O'Neill LP, Allan IM (1989). "Histone H4 acetylation in human cells. Frequency of acetylation at different sites defined by immunolabeling with site-specific antibodies". FEBS Lett. 253 (1–2): 141–5. Bibcode:1989FEBSL.253..141T. doi:10.1016/0014-5793(89)80947-0. PMID 2474456. S2CID 42476424.
• Pauli U, Chrysogelos S, Stein G, Stein J, Nick H (1987). "Protein-DNA interactions in vivo upstream of a cell cycle-regulated human H4 histone gene". Science. 236 (4806): 1308–11. Bibcode:1987Sci...236.1308P. doi:10.1126/science.3035717. PMID 3035717.
• Ebralidse KK, Grachev SA, Mirzabekov AD (1988). "A highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA". Nature. 331 (6154): 365–7. Bibcode:1988Natur.331..365E. doi:10.1038/331365a0. PMID 3340182. S2CID 4351515.
• Sierra F, Stein G, Stein J (1983). "Structure and in vitro transcription of a human H4 histone gene". Nucleic Acids Res. 11 (20): 7069–86. doi:10.1093/nar/11.20.7069. PMC 326439. PMID 6314274.
• Drabent B, Kardalinou E, Bode C, Doenecke D (1995). "Association of histone H4 genes with the mammalian testis-specific H1t histone gene". DNA Cell Biol. 14 (7): 591–7. doi:10.1089/dna.1995.14.591. PMID 7626218.
• Albig W, Meergans T, Doenecke D (1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.
• Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
• El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
• Albig W, Trappe R, Kardalinou E, Eick S, Doenecke D (1999). "The human H2A and H2B histone gene complement". Biol. Chem. 380 (1): 7–18. doi:10.1515/BC.1999.002. PMID 10064132. S2CID 12807248.
• Ahn J, Gruen JR (1999). "The genomic organization of the histone clusters on human 6p21.3". Mamm. Genome. 10 (7): 768–70. doi:10.1007/s003359901089. PMID 10384058. S2CID 28275496.
• Deng L, de la Fuente C, Fu P, Wang L, Donnelly R, Wade JD, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
• Deng L, Wang D, de la Fuente C, Wang L, Li H, Lee CG, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.