Glutamate carboxypeptidase (EC 3.4.17.11, carboxypeptidase G, carboxypeptidase G1, carboxypeptidase G2, glutamyl carboxypeptidase, N-pteroyl-L-glutamate hydrolase) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction
| Glutamate carboxypeptidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 | |||||||||
| Identifiers | |||||||||
| EC no. | 3.4.17.11 | ||||||||
| CAS no. | 9074-87-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups
This zinc enzyme is produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp.
See also
editReferences
edit- ^ Goldman P, Levy CC (October 1967). "Carboxypeptidase G: purification and properties". Proceedings of the National Academy of Sciences of the United States of America. 58 (4): 1299–306. Bibcode:1967PNAS...58.1299G. doi:10.1073/pnas.58.4.1299. PMC 223923. PMID 5237864.
- ^ McCullough JL, Chabner BA, Bertino JR (December 1971). "Purification and properties of carboxypeptidase G 1". The Journal of Biological Chemistry. 246 (23): 7207–13. doi:10.1016/S0021-9258(19)45873-0. PMID 5129727.
- ^ Albrecht AM, Boldizsar E, Hutchison DJ (May 1978). "Carboxypeptidase displaying differential velocity in hydrolysis of methotrexate, 5-methyltetrahydrofolic acid, and leucovorin". Journal of Bacteriology. 134 (2): 506–13. doi:10.1128/jb.134.2.506-513.1978. PMC 222280. PMID 26657.
- ^ Sherwood RF, Melton RG, Alwan SM, Hughes P (May 1985). "Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16. Use of a novel triazine dye affinity method". European Journal of Biochemistry. 148 (3): 447–53. doi:10.1111/j.1432-1033.1985.tb08860.x. PMID 3838935.
External links
edit- Glutamate+carboxypeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
