Gastric inhibitory polypeptide receptor

"GIPR" redirects here. For another use, see Great Indian Peninsular Railway.

The gastric inhibitory polypeptide receptor (GIP-R), also known as the glucose-dependent insulinotropic polypeptide receptor, is a protein that in humans is encoded by the GIPR gene.

GIPR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HJ0, 2QKH
Identifiers
Aliases	GIPR, PGQTL2, gastric inhibitory polypeptide receptor
External IDs	OMIM: 137241; MGI: 1352753; HomoloGene: 20081; GeneCards: GIPR; OMA:GIPR - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 45,668,221 bp End 45,683,722 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A3 Start 18,889,986 bp End 18,900,052 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube apex of heart right auricle olfactory zone of nasal mucosa body of pancreas granulocyte body of stomach islet of Langerhans minor salivary glands bronchial epithelial cell Top expressed in islet of Langerhans embryo morula spermatid blastocyst ventricular zone ganglionic eminence left lung lobe primary visual cortex superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity gastric inhibitory peptide receptor activity transmembrane signaling receptor activity protein binding peptide hormone binding G protein-coupled peptide receptor activity Cellular component integral component of membrane membrane plasma membrane Biological process response to fatty acid response to nutrient regulation of insulin secretion positive regulation of cytosolic calcium ion concentration response to glucose generation of precursor metabolites and energy activation of adenylate cyclase activity response to calcium ion cell surface receptor signaling pathway gastric inhibitory peptide signaling pathway response to axon injury desensitization of G protein-coupled receptor signaling pathway endocrine pancreas development signal transduction positive regulation of insulin secretion G protein-coupled receptor signaling pathway positive regulation of cAMP-mediated signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2696 381853 Ensembl ENSG00000010310 ENSMUSG00000030406 UniProt P48546 Q0P543 RefSeq (mRNA) NM_000164 NM_001308418 NM_001080815 RefSeq (protein) NP_000155 NP_001295347 NP_001074284 Location (UCSC) Chr 19: 45.67 – 45.68 Mb Chr 7: 18.89 – 18.9 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

GIP-R is a member of the class B family of G protein coupled receptors. GIP-R is found on beta-cells in the pancreas where it serves as the receptor for the hormone Gastric inhibitory polypeptide (GIP).

Function

Gastric inhibitory polypeptide, also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid polypeptide synthesized by K cells of the duodenum and small intestine. It was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release potently in the presence of elevated glucose. The insulinotropic effect on pancreatic islet beta-cells was then recognized to be the principal physiologic action of GIP. Together with glucagon-like peptide-1, GIP is largely responsible for the secretion of insulin after eating. It is involved in several other facets of the anabolic response.

Further reading

• Yamada Y, Seino Y (2005). "Physiology of GIP--a lesson from GIP receptor knockout mice". Horm. Metab. Res. 36 (11–12): 771–774. doi:10.1055/s-2004-826162. PMID 15655707. S2CID 262453421.
• Gremlich S, Porret A, Hani EH, Cherif D, Vionnet N, Froguel P, Thorens B (1995). "Cloning, functional expression, and chromosomal localization of the human pancreatic islet glucose-dependent insulinotropic polypeptide receptor". Diabetes. 44 (10): 1202–1208. doi:10.2337/diabetes.44.10.1202. PMID 7556958.
• Volz A, Göke R, Lankat-Buttgereit B, Fehmann HC, Bode HP, Göke B (1995). "Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma". FEBS Lett. 373 (1): 23–29. doi:10.1016/0014-5793(95)01006-Z. PMID 7589426. S2CID 25033358.
• Usdin TB, Mezey E, Button DC, Brownstein MJ, Bonner TI (1994). "Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain". Endocrinology. 133 (6): 2861–2870. doi:10.1210/endo.133.6.8243312. PMID 8243312.
• Yamada Y, Hayami T, Nakamura K, Kaisaki PJ, Someya Y, Wang CZ, Seino S, Seino Y (1996). "Human gastric inhibitory polypeptide receptor: cloning of the gene (GIPR) and cDNA". Genomics. 29 (3): 773–776. doi:10.1006/geno.1995.9937. PMID 8575774.
• Gallwitz B, Witt M, Morys-Wortmann C, Fölsch UR, Schmidt WE (1997). "GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1". Regul. Pept. 63 (1): 17–22. doi:10.1016/0167-0115(96)00019-5. PMID 8795084. S2CID 42462407.
• N'Diaye N, Tremblay J, Hamet P, De Herder WW, Lacroix A (1998). "Adrenocortical overexpression of gastric inhibitory polypeptide receptor underlies food-dependent Cushing's syndrome". J. Clin. Endocrinol. Metab. 83 (8): 2781–2785. doi:10.1210/jcem.83.8.5038. PMID 9709947.
• Tseng CC, Zhang XY (2000). "Role of G protein-coupled receptor kinases in glucose-dependent insulinotropic polypeptide receptor signaling". Endocrinology. 141 (3): 947–952. doi:10.1210/endo.141.3.7365. PMID 10698169.
• Bollag RJ, Zhong Q, Phillips P, Min L, Zhong L, Cameron R, Mulloy AL, Rasmussen H, Qin F (2000). "Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors". Endocrinology. 141 (3): 1228–1235. doi:10.1210/endo.141.3.7366. PMID 10698200.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Baldacchino V, Oble S, Hamet P, Tremblay J, Lacroix A (2003). "Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene". Endocr. Res. 28 (4): 577. doi:10.1081/ERC-120016843. PMID 12530665. S2CID 32639335.
• Antonini SR, N'Diaye N, Hamet P, Tremblay J, Lacroix A (2003). "Analysis of the putative promoter region of the GIP receptor gene (GIPR) in GIP-dependent Cushing's syndrome (CS)". Endocr. Res. 28 (4): 755–756. doi:10.1081/ERC-120017003. PMID 12530694. S2CID 21467413.
• Manhart S, Hinke SA, McIntosh CH, Pederson RA, Demuth HU (2003). "Structure-function analysis of a series of novel GIP analogues containing different helical length linkers". Biochemistry. 42 (10): 3081–3088. doi:10.1021/bi026868e. PMID 12627975.
• Ding KH, Zhong Q, Isales CM (2003). "Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1". Am. J. Physiol. Endocrinol. Metab. 285 (2): E390–6. doi:10.1152/ajpendo.00509.2002. PMID 12721154.
• Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–535. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
• Hansotia T, Baggio LL, Delmeire D, Hinke SA, Yamada Y, Tsukiyama K, Seino Y, Holst JJ, Schuit F (2004). "Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors". Diabetes. 53 (5): 1326–1335. doi:10.2337/diabetes.53.5.1326. PMID 15111503.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Baldacchino V, Oble S, Hamet P, Tremblay J, Bourdeau I, Lacroix A (2005). "The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter". Endocr. Res. 30 (4): 805–806. doi:10.1081/ERC-200044046. PMID 15666829. S2CID 40407171.

External links

• "Glucagon Receptor Family: GIP". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2007-10-25.
• gastric+inhibitory+polypeptide+receptor at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.