G protein nucleolar 3 like

G protein nucleolar 3 like is a protein that in humans is encoded by the GNL3L gene.

GNL3L
Identifiers
Aliases	GNL3L, GNL3B, G protein nucleolar 3 like
External IDs	OMIM: 300873; MGI: 2448557; HomoloGene: 134538; GeneCards: GNL3L; OMA:GNL3L - orthologs
Gene location (Human) Chr. X chromosome (human) Band Xp11.22 Start 54,530,183 bp End 54,621,521 bp
Gene location (Mouse) Chr. X chromosome (mouse) Band X|X F3 Start 149,766,137 bp End 149,800,318 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple sural nerve pylorus urethra epithelium of colon bone marrow cells human penis renal medulla superior surface of tongue monocyte Top expressed in genital tubercle dorsomedial hypothalamic nucleus tail of embryo paraventricular nucleus of hypothalamus ventral tegmental area habenula suprachiasmatic nucleus arcuate nucleus dentate gyrus of hippocampal formation granule cell piriform cortex More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding nucleotide binding GTP binding RNA binding GTPase activity Cellular component nucleus telomerase holoenzyme complex membrane nucleolus cytosol Biological process regulation of protein stability negative regulation of telomere maintenance via telomerase positive regulation of protein homodimerization activity negative regulation of protein sumoylation positive regulation of protein localization to chromosome, telomeric region negative regulation of protein ubiquitination negative regulation of protein binding ribosome biogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54552 237107 Ensembl ENSG00000130119 ENSMUSG00000025266 UniProt Q9NVN8 Q6PGG6 RefSeq (mRNA) NM_001184819 NM_019067 NM_001168600 NM_198110 RefSeq (protein) NP_001171748 NP_061940 NP_001162071 NP_932778 Location (UCSC) Chr X: 54.53 – 54.62 Mb Chr X: 149.77 – 149.8 Mb PubMed search
Wikidata
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Function

The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.

Further reading

• Du X, Rao MR, Chen XQ, Wu W, Mahalingam S, Balasundaram D (2006). "The homologous putative GTPases Grn1p from fission yeast and the human GNL3L are required for growth and play a role in processing of nucleolar pre-rRNA". Mol. Biol. Cell. 17 (1): 460–74. doi:10.1091/mbc.E05-09-0848. PMC 1345682. PMID 16251348.
• Rao MR, Kumari G, Balasundaram D, Sankaranarayanan R, Mahalingam S (2006). "A novel lysine-rich domain and GTP binding motifs regulate the nucleolar retention of human guanine nucleotide binding protein, GNL3L". J. Mol. Biol. 364 (4): 637–54. doi:10.1016/j.jmb.2006.09.007. PMID 17034816.
• Oktar PA, Yildirim S, Balci D, Can A (2011). "Continual expression throughout the cell cycle and downregulation upon adipogenic differentiation makes nucleostemin a vital human MSC proliferation marker". Stem Cell Rev. 7 (2): 413–24. doi:10.1007/s12015-010-9201-y. PMID 21063916. S2CID 1002010.
• Meng L, Hsu JK, Tsai RY (2011). "GNL3L depletion destabilizes MDM2 and induces p53-dependent G2/M arrest". Oncogene. 30 (14): 1716–26. doi:10.1038/onc.2010.550. PMC 3072457. PMID 21132010.
• Lin T, Meng L, Lin TC, Wu LJ, Pederson T, Tsai RY (2014). "Nucleostemin and GNL3L exercise distinct functions in genome protection and ribosome synthesis, respectively". J. Cell Sci. 127 (Pt 10): 2302–12. doi:10.1242/jcs.143842. PMC 6519424. PMID 24610951.
• Thoompumkal IJ, Subba Rao MR, Kumaraswamy A, Krishnan R, Mahalingam S (2015). "GNL3L Is a Nucleo-Cytoplasmic Shuttling Protein: Role in Cell Cycle Regulation". PLOS ONE. 10 (8): e0135845. Bibcode:2015PLoSO..1035845T. doi:10.1371/journal.pone.0135845. PMC 4537249. PMID 26274615.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.