Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZ gene .[ 5] [ 6]
The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systems. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids.[ 6]
^ a b c GRCh38: Ensembl release 89: ENSG00000128266 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040009 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Matsuoka M, Itoh H, Kaziro Y (September 1990). "Characterization of the human gene for Gx alpha, a pertussis toxin-insensitive regulatory GTP-binding protein" . J. Biol. Chem . 265 (22): 13215–20. doi :10.1016/S0021-9258(19)38287-0 PMID 2115889 . ^ a b "Entrez Gene: GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide" .^ a b Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins" . J. Biol. Chem . 275 (41): 32129–34. doi :10.1074/jbc.M004577200 PMID 10906137 . ^ Nagahama M, Usui S, Shinohara T, Yamaguchi T, Tani K, Tagaya M (December 2002). "Inactivation of Galpha(z) causes disassembly of the Golgi apparatus". J. Cell Sci . 115 (Pt 23): 4483–93. doi :10.1242/jcs.00093 . PMID 12414994 . S2CID 37993828 . ^ Glick JL, Meigs TE, Miron A, Casey PJ (October 1998). "RGSZ1, a Gz-selective regulator of G protein signaling whose action is sensitive to the phosphorylation state of Gzalpha" . J. Biol. Chem . 273 (40): 26008–13. doi :10.1074/jbc.273.40.26008 PMID 9748279 . ^ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (December 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits" . Proc. Natl. Acad. Sci. U.S.A . 93 (26): 15203–8. Bibcode :1996PNAS...9315203D . doi :10.1073/pnas.93.26.15203 PMC 26381 PMID 8986788 .
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