GLRX3

Glutaredoxin-3 is a protein that in humans is encoded by the GLRX3 gene.

GLRX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DIY, 2WZ9, 2YAN, 3ZYW
Identifiers
Aliases	GLRX3, GLRX4, GRX3, GRX4, PICOT, TXNL2, TXNL3, glutaredoxin 3
External IDs	OMIM: 612754; MGI: 1353653; HomoloGene: 4769; GeneCards: GLRX3; OMA:GLRX3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q26.3 Start 130,136,391 bp End 130,184,521 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 F4 Start 137,039,343 bp End 137,070,323 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell islet of Langerhans right testis left testis mucosa of esophagus right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex body of pancreas Top expressed in spermatid Ileal epithelium spermatocyte choroid plexus of fourth ventricle lactiferous gland yolk sac cardiac muscle tissue of left ventricle ventricular zone embryo genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-disulfide reductase activity electron transfer activity iron-sulfur cluster binding protein binding metal ion binding protein kinase C binding RNA binding identical protein binding glutathione disulfide oxidoreductase activity Cellular component cytoplasm dendrite cell cortex Z discdkac extracellular exosome nucleus cytosol Biological process cell redox homeostasis negative regulation of cardiac muscle hypertrophy regulation of the force of heart contraction [2Fe-2S cluster assembly] protein maturation by iron-sulfur cluster transfer electron transport chain cellular iron ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10539 30926 Ensembl ENSG00000108010 ENSMUSG00000031068 UniProt O76003 Q9CQM9 RefSeq (mRNA) NM_001199868 NM_006541 NM_001321980 NM_023140 NM_001348093 RefSeq (protein) NP_001186797 NP_001308909 NP_006532 NP_075629 NP_001335022 Location (UCSC) Chr 10: 130.14 – 130.18 Mb Chr 7: 137.04 – 137.07 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interactions

GLRX3 has been shown to interact with PRKCQ.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Overview of all the structural information available in the PDB for UniProt: O76003 (Human Glutaredoxin-3 (GLRX3)) at the PDBe-KB.