GGL domain is domain found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling RGS proteins.[1]
 Phosducin - transducin beta-gamma complex. Gamma subunit (GGL domain) colored red. | |||||||||||
| Identifiers | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Symbol | G-gamma | ||||||||||
| Pfam | PF00631 | ||||||||||
| InterPro | IPR001770 | ||||||||||
| SMART | GGL | ||||||||||
| PROSITE | PDOC01002 | ||||||||||
| SCOP2 | 1gp2 / SCOPe / SUPFAM | ||||||||||
| OPM protein | 2bcj | ||||||||||
| CDD | cd00068 | ||||||||||
| |||||||||||
Human proteins containing this domain
editSee also
editReferences
edit- ^ Snow BE, Krumins AM, Brothers GM, Lee SF, Wall MA, Chung S, Mangion J, Arya S, Gilman AG, Siderovski DP (1998). "A G protein γ subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gβ5 subunits". Proc. Natl. Acad. Sci. U.S.A. 95 (22): 13307–12. Bibcode:1998PNAS...9513307S. doi:10.1073/pnas.95.22.13307. PMC 23793. PMID 9789084.
Further reading
edit- Chatterjee TK, Liu Z, Fisher RA (August 2003). "Human RGS6 gene structure, complex alternative splicing, and role of N terminus and G protein gamma-subunit-like (GGL) domain in subcellular localization of RGS6 splice variants". J. Biol. Chem. 278 (32): 30261–71. doi:10.1074/jbc.M212687200. PMID 12761221.
- Chen CK, Eversole-Cire P, Zhang H, et al. (May 2003). "Instability of GGL domain-containing RGS proteins in mice lacking the G protein β-subunit Gβ5". Proc. Natl. Acad. Sci. U.S.A. 100 (11): 6604–9. Bibcode:2003PNAS..100.6604C. doi:10.1073/pnas.0631825100. PMC 164494. PMID 12738888.
- Liu Z, Chatterjee TK, Fisher RA (October 2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6". J. Biol. Chem. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.
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