GCHFR

GTP cyclohydrolase 1 feedback regulatory protein is an enzyme that in humans is encoded by the GCHFR gene.

GCHFR
Identifiers
Aliases	GCHFR, GFRP, HsT16933, P35, GTP cyclohydrolase I feedback regulator
External IDs	OMIM: 602437; MGI: 2443977; HomoloGene: 3849; GeneCards: GCHFR; OMA:GCHFR - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.1 Start 40,764,068 bp End 40,767,708 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E5 Start 118,998,254 bp End 119,002,871 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver olfactory zone of nasal mucosa mucosa of transverse colon right lung jejunal mucosa mucosa of ileum duodenum human kidney upper lobe of left lung oral cavity Top expressed in right kidney left lobe of liver proximal tubule olfactory epithelium jejunum interventricular septum embryo blood lobe of prostate human kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTP cyclohydrolase binding enzyme inhibitor activity amino acid binding protein binding enzyme binding GTP-dependent protein binding Cellular component cytoplasm cytosol nuclear membrane membrane melanosome dendrite nucleus nucleoplasm protein-containing complex Biological process nitric oxide biosynthetic process protein heterooligomerization negative regulation of GTP cyclohydrolase I activity neurotransmitter metabolic process negative regulation of biosynthetic process protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2644 320415 Ensembl ENSG00000137880 ENSMUSG00000046814 UniProt P30047 P99025 RefSeq (mRNA) NM_005258 NM_177157 RefSeq (protein) NP_005249 NP_796131 Location (UCSC) Chr 15: 40.76 – 40.77 Mb Chr 2: 119 – 119 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Yoneyama T, Brewer JM, Hatakeyama K (1997). "GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression". J. Biol. Chem. 272 (15): 9690–6. doi:10.1074/jbc.272.15.9690. PMID 9092499.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bader G, Schiffmann S, Herrmann A, et al. (2001). "Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP". J. Mol. Biol. 312 (5): 1051–7. doi:10.1006/jmbi.2001.5011. PMID 11580249.
• Werner ER, Bahrami S, Heller R, Werner-Felmayer G (2002). "Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein". J. Biol. Chem. 277 (12): 10129–33. doi:10.1074/jbc.M107326200. PMID 11799107.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gesierich A, Niroomand F, Tiefenbacher CP (2003). "Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism". Basic Res. Cardiol. 98 (2): 69–75. doi:10.1007/s00395-003-0394-y. PMID 12607127. S2CID 19864675.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kalivendi S, Hatakeyama K, Whitsett J, et al. (2006). "Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP?". Free Radic. Biol. Med. 38 (4): 481–91. doi:10.1016/j.freeradbiomed.2004.11.004. PMID 15649650.
• Chavan B, Gillbro JM, Rokos H, Schallreuter KU (2007). "GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes". J. Invest. Dermatol. 126 (11): 2481–9. doi:10.1038/sj.jid.5700425. PMID 16778797.
• Ohta E, Funayama M, Ichinose H, et al. (2006). "Novel mutations in the guanosine triphosphate cyclohydrolase 1 gene associated with DYT5 dystonia". Arch. Neurol. 63 (11): 1605–10. doi:10.1001/archneur.63.11.1605. PMID 17101830.
• Kontostavlaki DP, Panayotacopoulou MT, Sluijs JA, et al. (2007). "Co-expression of tyrosine hydroxylase and GTP cyclohydrolase I in arginine vasopressin-synthesizing neurons of the human supraoptic nucleus demonstrated by laser microdissection and real-time PCR". Neuroendocrinology. 84 (6): 386–95. doi:10.1159/000097487. PMID 17135716. S2CID 40550512.
• Nandi M, Kelly P, Vallance P, Leiper J (2008). "Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production". Vasc. Med. 13 (1): 29–36. doi:10.1177/1358863X07085916. PMID 18372436. S2CID 8626710.
• Ionova IA, Vasques-Vivar J, Whitsett J, et al. (2008). "Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes". Am. J. Physiol. 295 (5): H2178–87. doi:10.1152/ajpheart.00748.2008. PMC 2614582. PMID 18835915.