Galactoside 3(4)-L-fucosyltransferase is an enzyme that in humans is encoded by the FUT3 gene.[3][4][5]

FUT3
Identifiers
AliasesFUT3, CD174, FT3B, FucT-III, LE, Les, Fucosyltransferase 3, fucosyltransferase 3 (Lewis blood group)
External IDsHomoloGene: 128031; GeneCards: FUT3; OMA:FUT3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000149
NM_001097639
NM_001097640
NM_001097641
NM_001374740

n/a

RefSeq (protein)

n/a

Location (UCSC)Chr 19: 5.84 – 5.85 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Function

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The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.[5]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171124Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Kukowska-Latallo JF, Larsen RD, Nair RP, Lowe JB (Aug 1990). "A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase". Genes & Development. 4 (8): 1288–303. doi:10.1101/gad.4.8.1288. PMID 1977660.
  4. ^ Weston BW, Nair RP, Larsen RD, Lowe JB (Feb 1992). "Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities". The Journal of Biological Chemistry. 267 (6): 4152–60. doi:10.1016/S0021-9258(19)50641-X. PMID 1740457.
  5. ^ a b "Entrez Gene: FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)".

Further reading

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