Fatty acid transport proteins (FATPs, SLC27, SLC27A) are a family of trans-membrane transport proteins, which allow and enhance the uptake of long chain fatty acids into cells.[1] This subfamily is part of the solute carrier protein family. Within humans this family contains six very homologous proteins, which are expressed in all tissues of the body which use fatty acids:[2]
- SLC27A1 (FATP1) Long-chain fatty acid transport protein 1
- SLC27A2 (FATP2) Very long-chain acyl-CoA synthetase
- SLC27A3 (FATP3) Solute carrier family 27 member 3
- SLC27A4 (FATP4) Long-chain fatty acid transport protein 4
- SLC27A5 (FATP5) Bile acyl-CoA synthetase
- SLC27A6 (FATP6) Long-chain fatty acid transport protein 6
References
edit- ^ Houten, Sander Michel; Wanders, Ronald J. A. (October 2010). "A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation". Journal of Inherited Metabolic Disease. 33 (5): 469–477. doi:10.1007/s10545-010-9061-2. ISSN 1573-2665. PMC 2950079. PMID 20195903.
- ^ Doege, Holger; Stahl, Andreas (August 2006). "Protein-mediated fatty acid uptake: novel insights from in vivo models". Physiology. 21 (4): 259–268. doi:10.1152/physiol.00014.2006. ISSN 1548-9213. PMID 16868315.