FCHO1

FCH domain only 1 is a protein that in humans is encoded by the FCHO1 gene.

FCHO1
Identifiers
Aliases	FCHO1, FCH domain only 1, FCH and mu domain containing endocytic adaptor 1
External IDs	OMIM: 613437; MGI: 1921265; HomoloGene: 22869; GeneCards: FCHO1; OMA:FCHO1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.11 Start 17,747,718 bp End 17,788,568 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 B3.3 Start 72,161,031 bp End 72,178,360 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte C1 segment oocyte right frontal lobe blood right hemisphere of cerebellum lymph node monocyte putamen prefrontal cortex Top expressed in superior frontal gyrus primary visual cortex thymus perirhinal cortex entorhinal cortex cerebellar cortex dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord primary motor cortex olfactory tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function AP-2 adaptor complex binding protein binding phospholipid binding microtubule binding cytoskeletal protein binding tubulin binding Cellular component plasma membrane clathrin-coated pit membrane clathrin-coated vesicle nucleoplasm cytosol cytoplasm cytoskeleton AP-2 adaptor complex Biological process clathrin-dependent endocytosis endocytosis clathrin coat assembly membrane organization plasma membrane tubulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23149 74015 Ensembl ENSG00000130475 ENSMUSG00000070000 UniProt O14526 Q8K285 RefSeq (mRNA) NM_001161357 NM_001161358 NM_001161359 NM_015122 NM_028715 RefSeq (protein) NP_001154829 NP_001154830 NP_001154831 NP_055937 NP_082991 Location (UCSC) Chr 19: 17.75 – 17.79 Mb Chr 8: 72.16 – 72.18 Mb PubMed search
Wikidata
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Further reading

• Sakaushi S, Inoue K, Zushi H, Senda-Murata K, Fukada T, Oka S, Sugimoto K (2007). "Dynamic behavior of FCHO1 revealed by live-cell imaging microscopy: its possible involvement in clathrin-coated vesicle formation". Biosci. Biotechnol. Biochem. 71 (7): 1764–8. doi:10.1271/bbb.60720. PMID 17617719. S2CID 21432830.
• Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT (2010). "FCHo proteins are nucleators of clathrin-mediated endocytosis". Science. 328 (5983): 1281–4. Bibcode:2010Sci...328.1281H. doi:10.1126/science.1188462. PMC 2883440. PMID 20448150.
• Umasankar PK, Sanker S, Thieman JR, Chakraborty S, Wendland B, Tsang M, Traub LM (2012). "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning". Nat. Cell Biol. 14 (5): 488–501. doi:10.1038/ncb2473. PMC 3354769. PMID 22484487.